ReviewOxidative medicine and cellular longevity2021
The Critical Role of Oxidative Stress in Sarcopenic Obesity.
Review in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Intramuscular Fat Infiltration and Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Pooled it
- Systematic review and meta-analysis of biomarkers of sarcopenia and sarcopenic obesity.Medicine · 2026Pooled it
- The Role of Anthocyanins, Curcumin, and Resveratrol in the Prevention and Management of Metabolic Disorders: A Systematic Review.Molecules (Basel, Switzerland) · 2026Pooled it
- Dietary Inflammatory Potential and Bone Outcomes in Midwestern Post-Menopausal Women.Nutrients · 2023Trial
- Sex Differences in the Association Between Body Composition, Sarcopenic Obesity, and Periodontitis: Mediating Role of Oxidative Stress Markers.Oral health & preventive dentistry · 2026Article
- Revitalizing Muscles: Harnessing Exercise to Modulate Inflammatory Cytokines and Conquer Sarcopenia in Aging.Cell biochemistry and biophysics · 2026Review
- Locomotor muscle dysfunction and rehabilitative exercise training in fibrotic interstitial lung disease: Where are we at and where could we go?Experimental physiology · 2026Review
- Association of Sarcopenia With Cognitive Function in Patients With Parkinson's Disease: A Cross-Sectional Study.Brain and behavior · 2026Article
- Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults-A Narrative Review.Biomedicines · 2026Review
- Development of a sarcopenia identification model for older adults with multimorbidity in Xinjiang communities, Northwest China: a cross-sectional study.BMC geriatrics · 2026Article
- Comparative analysis of sarcopenic obesity detection and associated mental-cognitive outcomes in community-dwelling older adults: impact of using body mass index versus waist circumference.BMC geriatrics · 2026Article
- Composite dietary fiber alleviates obesity-induced skeletal muscle atrophy by regulating gut microbiota-derived short-chain fatty acids in mice.NPJ science of food · 2026Article
- Sedentary behavior and type 2 diabetes in community-dwelling middle-aged and older adults: indirect cross-sectional correlation of sarcopenic obesity.Frontiers in endocrinology · 2026Article
- The association between composite dietary antioxidant index and sarcopenic obesity.Nutrition & metabolism · 2025Article
- The Predictive Role of Thiol/Disulfide Homeostasis as an Oxidative Stress Parameter in Sarcopenic Obesity.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring Sarcopenic Obesity in the Cancer Setting: Insights from the National Health and Nutrition Examination Survey on Prognosis and Predictors Using Machine Learning.Bioengineering (Basel, Switzerland) · 2025Article
- 5,7-Dimethoxyflavone Attenuates Sarcopenic Obesity by Enhancing PGC-1α-Mediated Mitochondrial Function in High-Fat-Diet-Induced Obese Mice.Nutrients · 2025Article
- The Role of Rehabilitation Program in Managing the Triad of Sarcopenia, Obesity, and Chronic Pain.Life (Basel, Switzerland) · 2025Article
- Protocol for a Trial to Assess the Efficacy and Applicability of Isometric Strength Training in Older Adults with Sarcopenia and Dynapenia.Healthcare (Basel, Switzerland) · 2025Article
- Bidirectional association between grip strength and cognitive function in Chinese older adults: a nationwide cohort study.BMC public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenic obesity (SO) is a combination of obesity and sarcopenia that primarily develops in older people. Patients with SO have high fat mass, low muscle mass, low muscle strength, and low physical function. SO relates to metabolic syndrome and an increased risk of morbimortality. The prevalence of SO varies because of lacking consensus criteria regarding its definition and the methodological difficulty in diagnosing sarcopenia and obesity. SO includes systemic alterations such as insulin resistance, increased proinflammatory cytokines, age-associated hormonal changes, and decreased physical activity at pathophysiological levels. Interestingly, these alterations are influenced by oxidative stress, which is a critical factor in altering muscle function and the generation of metabolic dysfunctions. Thus, oxidative stress in SO alters muscle mass, the signaling pathways that control it, satellite cell functions, and mitochondrial and endoplasmic reticulum activities. Considering this background, our objectives in this review are to describe SO as a highly prevalent condition and look at the role of oxidative stress in SO pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.