ArticleFrontiers in immunology2021
Short Chain Fatty Acids Prevent Glyoxylate-Induced Calcium Oxalate Stones by GPR43-Dependent Immunomodulatory Mechanism.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The gut-kidney microbiome-oxalate axis in calcium oxalate nephrolithiasis: mechanisms and microbiome-based interventions.Frontiers in cellular and infection microbiology · 2026Pooled it
- Metabolic changes in kidney stone disease.Frontiers in immunology · 2023Pooled it
- Gut microbiota: a novel key player in urinary stone formation - from oxalate metabolism to systemic regulation.Gut microbes · 2026Review
- Paishi granule inhibits calcium oxalate-induced oxidative stress kidney injury after gut microbiota transformation: a multi-omics analysis combined in vivo and in vitro study.Chinese medicine · 2026Article
- The roles of free-fatty acid receptors in the pathophysiology of renal disorders.The Journal of pharmacology and experimental therapeutics · 2026Review
- Animal models for calcium oxalate kidney stone research.Zoological research · 2026Review
- Sex-specific signatures of gut microbiota and systemic inflammation in patients with urolithiasis: a cross-sectional study.Frontiers in cellular and infection microbiology · 2026Article
- Gut microbiota metabolite butyric acid alleviatedBurns & trauma · 2026Article
- Adherence to the Dietary Index for Gut Microbiota and reduced risk of nephrolithiasis: a case-control study of Chinese adults.Frontiers in nutrition · 2026Article
- Article
- The effects of immune cells and blood metabolites on kidney stones: a bidirectional two-sample Mendelian randomization study and mediation analysis.International urology and nephrology · 2025Article
- Chrono-Synergistic Nutrition: Gut Microbiota-Targeted Diets and Circadian-Aligned First Meal Timing Confer Robust Protection Against Kidney Stone Formation.Food science & nutrition · 2025Article
- Gut microbiota-regulated unconjugated bilirubin metabolism drives renal calcium oxalate crystal deposition.Gut microbes · 2025Article
- [Reduced intestinal abundance ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Dysbiosis of gut and urinary microbiota in urolithiasis patients and post-surgical cases.Frontiers in cellular and infection microbiology · 2025Article
- The gut-kidney axis in urolithiasis: roles of gut microbiota, metabolites, and therapeutic implications.Frontiers in microbiology · 2025Review
- Research progress on the mechanisms of interleukin and chemokine families in driving calcium oxalate nephrolithiasis formation.Frontiers in immunology · 2025Review
- Single-Cell RNA Sequencing Analysis Reveals the Role of Macrophage-Mediated CD44-AKT-CCL2 Pathways in Renal Tubule Injury during Calcium Oxalate Crystal Formation.Research (Washington, D.C.) · 2025Article
- How is the human microbiome linked to kidney stones?Frontiers in cellular and infection microbiology · 2025Review
- A high-calorie diet exacerbates lipopolysaccharide-induced pneumonia by promoting acetate-mediated macrophage polarization via the HDAC9/10-HIF-1α-glycolysis axis.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium oxalate (CaOx) stones are the most common type of kidney stones and are associated with high recurrence, short chain fatty acids (SCFAs), and inflammation. However, it remains uncertain whether SCFAs affect the formation of CaOx stones through immunomodulation. We first performed mass cytometry (CyTOF) and RNA sequencing on kidney immune cells with glyoxylate-induced CaOx crystals (to elucidate the landscape of the associated immune cell population) and explored the role of SCFAs in renal CaOx stone formation through immunomodulation. We identified 29 distinct immune cell subtypes in kidneys with CaOx crystals, where CX3CR1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.