Evidence map›Paper›PMID 34675916›Full record

ArticleFrontiers in immunology2021

Neutrophil Dynamics Affect

Caitlin Hult, Joshua T Mattila, Hannah P Gideon, Jennifer J Linderman, Denise E Kirschner

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. HowVaccines · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Necrosis drives susceptibility toInfection and immunity · 2025
    Article
  12. Review
  13. GEODE: anFrontiers in pharmacology · 2025
    Article
  14. Frontiers in immunology · 2025
    Article
  15. Article
  16. Necrosis drives susceptibility tobioRxiv : the preprint server for biology · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Caitlin HultDepartment of Mathematics, Gettysburg College, Gettysburg, PA, United States.
Joshua T MattilaDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States.
Hannah P GideonCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, United States.
Jennifer J LindermanDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States.
Denise E KirschnerDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · USUniversity of Pittsburgh · USGettysburg College · US

Funding

Predicting immune responses that correlate with protection against tuberculosisR01HL110811 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2012 to 2016
$5.9M
Predicting protective T-cell responses in Tuberculosis using a systems biology approachR01AI123093 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2016 to 2020
$3.6M
NHLBI NIH HHS R01 HL110811NIAID NIH HHS R01 AI123093
6 · The paper itself

Abstract

Neutrophil infiltration into tuberculous granulomas is often associated with higher bacteria loads and severe disease but the basis for this relationship is not well understood. To better elucidate the connection between neutrophils and pathology in primate systems, we paired data from experimental studies with our next generation computational model

Indexed as

Computer SimulationModels, ImmunologicalNeutrophil InfiltrationAdaptive ImmunityAnimalsBacterial LoadCalibrationChemotaxis, LeukocyteCytokinesImmunity, InnateMacaca fascicularisMycobacterium tuberculosisNeutrophilsPhagocytosisTuberculomaCytokinesagent-based model (ABM)disseminationneutrophilnonhuman primate (NHP)sensitivity analysis (SA)tuberculosis (TB)

Identifiers

PMID34675916
PMCPMC8525425
OpenAlexW3204005454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.