Evidence map›Paper›PMID 34675898›Full record

ArticleFrontiers in microbiology2021

A Substituted Diphenyl Amide Based Novel Scaffold Inhibits

Biswajit Mishra, Rajamohammed Khader, Lewis Oscar Felix, Marissa Frate, Eleftherios Mylonakis, Susan Meschwitz, Beth Burgwyn Fuchs

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Evaluation of Amlodipine and Imipramine Efficacy to TreatAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Microorganisms · 2023
    Review
  7. Critical Assessment of the Prospects of Quorum-Quenching Therapy forInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Biswajit MishraDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, United States.
Rajamohammed KhaderDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, United States.
Lewis Oscar FelixDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, United States.
Marissa FrateDepartment of Chemistry, Salve Regina University, Newport, RI, United States.
Eleftherios MylonakisDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, United States.
Susan MeschwitzDepartment of Chemistry, Salve Regina University, Newport, RI, United States.
Beth Burgwyn FuchsDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, United States.
Brown University · USRhode Island Hospital · USSalve Regina University · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
Using Genomic Epidemiology to Identify Transmission Patterns and Inform Intervention Strategies for Antibiotic-Resistant N. GonorrhoeaeP20GM121344 · NIGMS · MIRIAM HOSPITAL · PI D'AGATA, ERIKA M · 2018 to 2022
$9.4M
NIGMS NIH HHS P20 GM103430NIGMS NIH HHS P20 GM121344
6 · The paper itself

Abstract

Antimicrobial compounds can combat microbes through modulating host immune defense, inhibiting bacteria survival and growth, or through impeding or inhibiting virulence factors. In the present study, a panel of substituted diphenyl amide compounds previously found to disrupt bacterial quorum sensing were investigated and several were found to promote survival in the

Indexed as

antimicrobial compoundsdrug discoveryGalleria mellonellaquorum sensing antagonistStaphylococcus aureusvirulence

Identifiers

PMID34675898
PMCPMC8524085
OpenAlexW3207192754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.