ArticleFrontiers in endocrinology2021
Prognostic Value of Preoperative Serum Calcitonin Levels for Predicting the Recurrence of Medullary Thyroid Carcinoma.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- ESR Essentials: thyroid imaging-practice recommendations by the European Society of Head and Neck Radiology.European radiology · 2026Guideline
- MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis.Updates in surgery · 2026Article
- Predicting Structural Progression-Free Survival After Surgery for Medullary Thyroid Carcinoma.World journal of surgery · 2026Observational
- Combined Detection of Preoperative Serum Calcitonin and Carcinoembryonic Antigen in Medullary Thyroid Carcinoma: A Retrospective Multicenter Cohort Study.Health care science · 2026Article
- Multifocality as a marker of aggressiveness in medullary thyroid carcinoma: a retrospective cohort analysis of lymph node metastasis and recurrence.The oncologist · 2026Article
- Prediction of distant metastases at diagnosis in medullary thyroid cancer: combining calcitonin with lymph node imaging.Journal of the Endocrine Society · 2026Article
- Diagnostic value of calcitonin for lateral cervical lymph node metastasis in medullary thyroid carcinoma: a systematic review and meta-analysis.Frontiers in oncology · 2026Review
- Evaluating the necessity of prophylactic lateral neck dissection in medullary thyroid carcinoma based on preoperative calcitonin levels: a multicenter retrospective cohort study.International journal of surgery (London, England) · 2026Article
- Medullary Thyroid Carcinoma Detected by Routine Health Screening Had Better Clinical Outcome and Survival.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Diagnostic value of preoperative systemic inflammatory markers and carcinoembryonic antigen in medullary thyroid carcinoma and the risk factors affecting its prognosis.Gland surgery · 2025Article
- Diagnostic value of contrast-enhanced ultrasound combined with serum procalcitonin in tuberculous lymph nodes and metastatic lymph nodes.Clinics (Sao Paulo, Brazil) · 2025Article
- Diagnostic challenges in calcitonin negative medullary thyroid carcinoma: a systematic review of 101 cases.Gland surgery · 2024Review
- Time Kinetics and prognosis roles of calcitonin after surgery for medullary thyroid carcinoma.World journal of surgical oncology · 2024Article
- Changes of biochemical factors and the effect on recurrence of medullary thyroid carcinoma after surgery.Heliyon · 2024Article
- Preoperative identification of low-risk medullary thyroid carcinoma: potential application to reduce total thyroidectomy.Scientific reports · 2023Article
- An Overview of Circulating Biomarkers in Neuroendocrine Neoplasms: A Clinical Guide.Diagnostics (Basel, Switzerland) · 2023Review
- Does pretreatment elevated calcitonin level cause the poor prognosis in patients with medullary thyroid cancer?Annals of translational medicine · 2022Article
- Early postoperative calcitonin-to-preoperative calcitonin ratio as a predictive marker for structural recurrence in sporadic medullary thyroid cancer: A retrospective study.Frontiers in endocrinology · 2022Article
- Construction and Validation of a Prediction Model for Identifying Clinical Risk Factors of Lateral Lymph Node Metastasis in Medullary Thyroid Carcinoma.International journal of general medicine · 2022Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Serum calcitonin level is a useful biomarker for predicting primary tumor size, the extent of lymph node, and distant metastasis in patients with medullary thyroid carcinoma (MTC). However, the association between preoperative serum calcitonin levels and long-term oncologic outcomes has not yet been established. The aims of this study were to determine the preoperative serum calcitonin cut-off value for predicting disease recurrence and to evaluate its prognostic value. Methods: Patients with MTC ( Results: The overall disease-free survival rate was 75.7%. The preoperative serum calcitonin cut-off value that predicted structural recurrence was 309 pg/mL. Preoperative serum calcitonin levels of > 309 pg/mL were the strongest independent predictor of disease recurrence (hazard ratio (HR) 5.33, 95% confidence interval (85% CI) 1.67-16.96; Conclusions: The preoperative serum calcitonin cut-off value is useful in clinical practice. It is also the best predictive factor for disease-free survival. Preoperative serum calcitonin levels may help determine the optimal postoperative follow-up strategy for patients with MTC.
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