Evidence map›Paper›PMID 34675809›Full record

ArticleFrontiers in pharmacology2021

Disease-Modifying Anti-rheumatic Drug Prescription Baihu-Guizhi Decoction Attenuates Rheumatoid Arthritis via Suppressing Toll-Like Receptor 4-mediated NLRP3 Inflammasome Activation.

Weijie Li, Xia Mao, Xiaoyue Wang, Yudong Liu, Kexin Wang, Congchong Li, Taixian Li, Yanqiong Zhang, Na Lin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  4. Battling pain from osteoarthritis: causing novel cell death.Acta biochimica et biophysica Sinica · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Weijie LiInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Xia MaoInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaoyue WangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yudong LiuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Kexin WangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Congchong LiInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Taixian LiInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yanqiong ZhangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Na LinInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a traditional Chinese medicine-originated disease-modifying anti-rheumatic drug prescription, Baihu-Guizhi decoction (BHGZD) is extensively used for the treatment of rheumatoid arthritis (RA) with a satisfying therapeutic efficacy. Mechanically, our previous data indicated that BHGZD may ameliorate RA partially by restoring the balance of the "inflammation-immune" system through regulating the

Indexed as

Baihu-Guizhi decoctionbalance of the “inflammation-immune” systempyroptosisrheumatoid arthritisTLR4-NLRP3 inflammasome signaling

Identifiers

PMID34675809
PMCPMC8525175
OpenAlexW3203486699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.