ArticleNature and science of sleep2021
The Associations of Trajectory of Sleep Duration and Inflammation with Hypertension: A Longitudinal Study in China.
Article in Nature and science of sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Association between sleep duration and hypertension incidence: Systematic review and meta-analysis of cohort studies.PloS one · 2024Pooled it
- Sex Differences in Sleep Duration and Quality: Implications for Hypertension Risk.Current hypertension reports · 2026Review
- Sleep duration and incidence of hypertension in the Bandare-Kong cohort study: findings from PERSIAN cohort study.BMC public health · 2025Article
- The relationship between fatigue and insomnia in ischemic stroke convalescence patients: the chained mediation effects of social support and anxiety.BMC neurology · 2025Article
- A [Journal of neuroinflammation · 2025Article
- Association of sleep duration with hypertension in young and middle-aged adults: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Findings and Methodological Shortcomings of Investigations Concerning the Relationship Between Sleep Duration and Blood Pressure: A Comprehensive Narrative Review.Journal of cardiovascular development and disease · 2025Review
- Review
- Sleep duration and mortality in patients with chronic noncommunicable disease: a population-based cohort study.Environmental health and preventive medicine · 2024Article
- Hypertension in China: epidemiology and treatment initiatives.Nature reviews. Cardiology · 2023Review
- Sleep duration trajectories and all-cause mortality among Chinese elderly: A community-based cohort study.BMC public health · 2023Article
- High-risk population and factors of stroke has changed among middle-aged and elderly Chinese-Evidence from 1989 to 2015.Frontiers in public health · 2023Article
- Secular Trends in Sleep Conditions in Chinese Elderly Individuals: A National Population-Based Study.Nature and science of sleep · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExisting evidence suggested that sleep duration may be involved in hypertension; however, the conclusions were still controversial. This study aimed to examine the association of longitudinal trajectory of sleep duration with hypertension and to explore the role of the inflammation in such associations.
methodsA total of 3178 subjects over 30 years of age without hypertension were enrolled in 2004, and they were followed until 2009. Self-reported sleep duration was recorded, and inflammation was measured by highly sensitive C reactive protein (hs-CRP). Log-binomial regression models were applied to examine the association of sleep duration trajectory and inflammation with the risk of hypertension. The mediating effect of elevated hs-CRP was examined by the bootstrap and the process software.
resultsThe prevalence of persistent short (≤7 hours/day), normal (8-9 hours/day), and long (>9 hours/day) sleep duration over 5 years were 9.1%, 37.7%, and 2.3%, respectively. The incidence of hypertension was 26.6% during the follow-up period. Compared with those who persistently slept 8-9 hours/day from baseline to follow-up, those who persistently slept ≤7 hours/day, persistently slept ≥10 hours/day, and those whose sleep duration changed have higher risks of hypertension by 1.375-fold (95% CI: 1.121, 1.686), 1.557-fold (95% CI: 1.171, 2.069) and 1.299-fold (95% CI: 1.135, 1.487), respectively. In addition, persistently slept ≤7 hours/day was found to be associated with higher risk of inflammation (RR: 1.285, 95% CI: 1.008, 1.638). The mediation analysis did not find significant mediating effect of elevated CRP on the association between sleep duration trajectory and hypertension.
conclusionExperiencing both a short or long sleep duration, especially for a long time, could lead to higher risk of hypertension. Persistent exposure to short sleep duration was also associated with inflammation. However, the higher risk of hypertension caused by persistent short sleep duration does not seem to be directly mediated through inflammation.
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