Evidence map›Paper›PMID 34675682›Full record

ArticleClinical epidemiology2021

Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study.

G David Batty, Catharine R Gale

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

G David BattyDepartment of Epidemiology and Public Health, University College London, London, UK.ORCID 0000-0003-1822-5753
Catharine R GaleMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
MRC Lifecourse Epidemiology Unit · GBUniversity College London · GB

Funding

Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60R01AG052519 · NIA · UNIVERSITY COLLEGE LONDON · PI BATTY, DAVID, GOODMAN, ALISSA · 2017 to 2021
$1.9M
Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60R56AG052519 · NIA · UNIVERSITY COLLEGE LONDON · PI BATTY, DAVID, GOODMAN, ALISSA · 2016 to 2016
$500k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/P023444/1NIA NIH HHS R01 AG052519NIA NIH HHS R56 AG052519
6 · The paper itself

Abstract

aimIn the absence of effective treatments for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder with high case fatality, there is a clear need to identify its primary risk factors.

methodsUK Biobank is a prospective cohort study in which baseline data were captured between 2006 and 2010 in 502,649 participants aged 37 to 73 years. Follow-up for ALS hospitalisations and death was made via national registries.

resultsEleven years of event surveillance gave rise to 301 hospitalisations and 279 deaths due to ALS. After adjustment for selected confounding factors, being older (hazard ratio per 10 year increase; 95% confidence interval: 1.92; 1.58, 2.33) and male (1.37; 1.00, 1.87) were associated with elevated rates of hospitalisation for ALS. Similar effects were apparent when death ascribed to the disorder was the outcome of interest. Of the remaining 23 social, biological, and behavioural risk indices, however, there was only a suggestion that taller people experienced an increased risk of hospitalisation (per SD increase: 1.31; 1.09, 1.59).

conclusionIn the present, large-scale study, other than well known associations, we did not find convincing evidence of links with ALS for other risk indices.

Indexed as

amyotrophic lateral sclerosiscohort studyrisk factorsUK Biobank

Identifiers

PMID34675682
PMCPMC8505194
OpenAlexW3204401045

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.