Evidence map›Paper›PMID 34675672›Full record

ArticleCancer management and research2021

A Survival Prediction Nomogram for Esophageal Squamous Cell Carcinoma Treated with Neoadjuvant Chemoradiotherapy Followed by Surgery.

Tianyan Ding, Cantong Liu, Binliang Huang, Lingyu Chu, Laifeng Wei, Yiwei Lin, Yun Luo, Biao Zhang, Chaoqun Hong, Yiwei Xu and 1 more

Abstract read
In one paragraph

Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianyan Ding *Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Cantong Liu *Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Binliang HuangDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Lingyu ChuDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.ORCID 0000-0002-4682-0931
Laifeng WeiDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Yiwei LinDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Yun LuoDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Biao ZhangDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Chaoqun HongGuangdong Provincial Key Laboratory of Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Yiwei XuDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.ORCID 0000-0002-8670-592X
Yuhui PengDepartment of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeoadjuvant chemoradiotherapy (NCRT) followed by surgery is a component of the standard treatment for resectable locally advanced esophageal squamous cell carcinoma (ESCC), and the parameters for survival prediction are not clear yet. Our study aimed to construct a survival prediction nomogram for ESCC with NCRT followed by surgery.

methodsWe analyzed hematological parameters and related-derivative indexes from 122 ESCC patients treated with NCRT followed by surgery. Univariate and multivariate Cox survival analyses were performed to identify independent prognostic factors to establish a nomogram and predict overall survival (OS). The predictive value of the nomogram for OS was evaluated by the concordance index (C-index), decision curve analysis (DCA), the clinical impact curve (CIC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI).

resultsThe pretreatment nutritional candidate, prognostic nutrition index, inflammation-related absolute monocyte count and TNM staging were entered into the nomogram for ESCC with NCRT followed by surgery. The C-index of the nomogram for OS was 0.790 (95% CI = 0.688-0.893), which was higher than that of TNM staging (0.681; 95% CI = 0.565-0.798, P = 0.026). The DCA, CIC, NRI, and IDI of the nomogram showed moderate improvement in predicting survival. Based on the cut point calculated according to the constructed nomogram, the high-risk group had poorer OS than that of the low-risk group (P < 0.05).

conclusionA novel nomogram based on nutrition- and inflammation-related indicators might help predict the survival of ESCC treated with NCRT followed by surgery.

Indexed as

esophageal squamous cell carcinomaneoadjuvant chemoradiotherapynomogramprognosissurgerysurvival

Identifiers

PMID34675672
PMCPMC8519412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.