ArticleCancer management and research2021
Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study.
Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Colorectal cancer incidence and survival trends in Uganda: a population-based registry analysis (2000-20).International journal of epidemiology · 2026Article
- Evaluating clinicopathological pattern and management of colorectal cancer for adult patients presenting at Queen Elizabeth Central Hospital: a 10-year retrospective review.BMC gastroenterology · 2026Article
- Carbonyl reductase 4 suppresses colorectal cancer progression through the DNMT3B/CBR4/FASN/mTOR axis.Cancer cell international · 2025Article
- Death domain-associated protein (Daxx) impairs colon cancer chemotherapy by inhibiting the cGAS-STING pathway.Oncology research · 2025Article
- Colorectal cancer research priorities in Uganda: perspectives from local key experts and stakeholders.Future oncology (London, England) · 2024Article
- Determination of the frequency and distribution of APC, PIK3CA, and SMAD4 gene mutations in Ugandan patients with colorectal cancer.BMC cancer · 2024Article
- Dietary risk factors for colorectal cancer in Uganda: a case-control study.BMC nutrition · 2024Article
- Colorectal cancer disease profile and treatment patterns at an urban tertiary hospital in Rwanda.Ecancermedicalscience · 2024Article
- Gene expression and anticancer evaluation of Kigelia africana (Lam.) Benth. Extracts using MDA-MB-231 and MCF-7 cell lines.PloS one · 2024Article
- Remote training and teleproctoring in gastrointestinal endoscopy for practicing surgeon in rural Uganda.Surgical endoscopy · 2023Article
- FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression.International journal of biological sciences · 2023Article
- Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa.Cancer management and research · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionColorectal cancer (CRC) is the most common type of gastrointestinal malignancies and the third leading cause of cancer-related deaths for both sexes worldwide. Although the burden of CRC is highest in developed countries, reports are indicating a rise in the incidence of early-onset CRC in developing countries. In this study, we aimed to determine the prevalence of CRC among patients hospitalized with lower gastrointestinal complaints at a tertiary health facility in Uganda.
methodsWe conducted a 10-year retrospective chart review of patients admitted to Mulago National Referral Hospital in Kampala, Uganda, between 1st January 2010 and 31st December 2020. We reviewed all charts of patients admitted to the lower gastrointestinal tract (GIT) ward. Charts with grossly missing data, pediatric patients, and those from other non-lower GIT specialties were excluded.
resultsData of 1476 unique eligible patients were analyzed. Of these,138 had a diagnosis of CRC (prevalence: 9.3%, 95% confidence interval (95% CI): 6.5-11.7%). Among patients with CRC, the female:male ratio was 1:1. The most common site for CRC was the rectum (59.8%, n= 79). For the 138 participants with CRC, 44 had staging data with 72.8% (n=32) having advanced disease, that is, stage 3 or 4. Factors independently associated with CRC were age ≥50 years (adjusted odds ratio (aOR): 4.3, 95% CI: 2.6-7.1, p < 0.001), female sex (aOR: 1.8, 95% CI: 1.2 -2.8, p = 0.005), being widowed (aOR: 2.5, 95% CI: 1.3-5.0, p = 0.006), and presence of any risk factor for CRC (aOR: 5.3, 95% CI: 2.9-9.9, p < 0.001).
conclusionCRC is relatively common among patients hospitalized with lower GIT complaints, particularly among women and those with known risk factors for CRC. Awareness creation and screening programs should be instituted to allow early diagnosis of CRC in our setting.
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