ArticleJournal of inflammation research2021
Investigating Associations Between Depressive Symptoms and Anti-/Pro-Inflammatory Nutrients in an Elderly Population in Northern China: A Bayesian Kernel Machine Regression Approach.
Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association Between Anti-Inflammatory Diet, Dietary Diversity, and Depressive Symptoms Among Chinese Pregnant Women.Nutrients · 2025Article
- Gender-specific associations of blood immune markers with symptoms and cognitive function in major depressive disorder: a cross-sectional observational study.BMC psychiatry · 2025Observational
- Joint Effect of Inflammatory Dietary Patterns and Physical Activity on the Risk of Depressive Symptoms: A Nation-Wide Cross-Sectional Study.Yonsei medical journal · 2025Article
- Association Between the Dietary Inflammatory Index and Depression in Mid-Pregnancy: Mediating Effect of Sleep Quality.Nutrients · 2025Article
- Using three statistical methods to analyze the associations between a mixture of multi-nutrients and risk of mild cognitive impairment in an elderly population in Northern China.Scientific reports · 2024Article
- Relationships between minerals' intake and blood homocysteine levels based on three machine learning methods: a large cross-sectional study.Nutrition & diabetes · 2024Article
- Interrogating Components of 2 Diet Quality Indices in Pregnancy using a Supervised Statistical Mixtures Approach.The American journal of clinical nutrition · 2023Article
- Dietary Inflammatory Nutrients and Esophageal Squamous Cell Carcinoma Risk: A Case-Control Study.Nutrients · 2022Article
- Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly.Nutrients · 2022Article
- Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.BMC medicine · 2022Article
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8 authors.
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Abstract
backgroudThe potential for dietary inflammation has been shown to be associated with a variety of chronic diseases. The relationship between the potential for dietary inflammation and depression in the elderly is unclear.
objectiveThis study aimed to exam the relationship between different nutrients and the risk of depression symptoms in the elderly.
methodsIn total, 1865 elderly in northern China were investigated at baseline from 2018 to 2019 and followed up in 2020. We measured the baseline intake of 22 nutrients and used Least Absolute Shrinkage and Selection Operator(LASSO) regression analysis and Bayesian Kernel Machine Regression (BKMR) to explore the association between exposure to a variety of nutrients with different inflammatory potentials and the risk of depressive symptoms.
resultsA total of 447 individuals (24.0%) were diagnosed with depressive symptoms. Through the lasso regression model, it was found that 11 nutrients are significantly related to the risk of depressive symptoms, of which 6 nutrients are pro-inflammatory nutrients (inflammation effect score>0), and 5 are anti-inflammatory nutrients (inflammation effect score<0). We incorporated the inflammatory effect scores of 11 nutrients into the BKMR model at the same time, and found that the overall inflammatory effect of 11 nutrients increased with the increase of total inflammatory scores, suggesting that the overall effect was pro-inflammatory. BKMR subgroup analysis shows that whether in the pro-inflammatory nutrient group or the anti-inflammatory nutrient group, multiple nutrients have a significant combined effect on depressive symptoms. By comparing the overall and group effects, we found that the inflammatory effects of the pro-inflammatory diet and the anti-inflammatory diet in the study's diet are offset by each other (P<0.005).
conclusionWe determined the combined effect of multiple nutrients of different inflammatory potential classifications on depressive symptoms in the elderly.
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