Evidence map›Paper›PMID 34675561›Full record

ArticleInfection and drug resistance2021

COVID-19, HIV-Associated Cryptococcal Meningitis, Disseminated Tuberculosis and Acute Ischaemic Stroke: A Fatal Foursome.

Felix Bongomin, Senai Goitom Sereke, Jerom Okot, Ronald Katsigazi, Tadeo Kiiza Kandole, Anthony Oriekot, Ronald Olum, Angella Atukunda, Joseph Baruch Baluku, Frederick Nakwagala

Open access · goldAbstract readCase Reports
In one paragraph

Article in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. COVID-19 associated with cryptococcosis: a scoping review.Therapeutic advances in infectious disease
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Felix BongominDepartment of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0003-4515-8517
Senai Goitom SerekeDepartment of Radiology and Radiotherapy, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Jerom OkotDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.ORCID 0000-0002-4160-6418
Ronald KatsigaziDepartment of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Tadeo Kiiza KandoleInfectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Anthony OriekotDivision of Pulmonology, Kiruddu National Referral Hospital, Kampala, Uganda.
Ronald OlumDepartment of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0003-1289-0111
Angella AtukundaDepartment of Medicine, Mulago National Referral Hospital, Kampala, Uganda.
Joseph Baruch BalukuDivision of Pulmonology, Kiruddu National Referral Hospital, Kampala, Uganda.ORCID 0000-0002-5852-9674
Frederick NakwagalaDepartment of Medicine, Mulago National Referral Hospital, Kampala, Uganda.
Makerere University · UGGulu University · UGMulago Hospital · UGInfectious Diseases Institute · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral viral, bacterial and fungal co-infections have been associated with increased morbidity and mortality among patients with COVID-19. We report a fatal case of severe COVID-19 pneumonia in a patient with a recent diagnosis of advanced HIV disease complicated by cryptococcal meningitis, disseminated tuberculosis and acute ischemic stroke. CASE PRESENTATION: A 37-year-old Ugandan woman was diagnosed with HIV infection 8 days prior to her referral to our center. She was antiretroviral naïve. Her chief complaints were worsening cough, difficulty in breathing, fever and altered mental status for 3 days with a background of a 1-month history of coughing with associated drenching night sweats and weight loss. The reverse transcriptase-polymerase chain reaction for SARS-CoV-2 of her nasopharyngeal swab sample was positive. Chest radiograph demonstrated military pattern involvement of both lungs. The serum and cerebrospinal fluid cryptococcal antigen tests were positive. Urine lipoarabinomannan and sputum GeneXpert were positive for

conclusionCo-infections worsen COVID-19 outcomes.

Indexed as

co-infectionCOVID-19cryptococcal meningitisHIVstroketuberculosis

Identifiers

PMID34675561
PMCPMC8517634
OpenAlexW3202809258

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.