Evidence map›Paper›PMID 34675484›Full record

ArticleDrug design, development and therapy2021

Development and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications.

Evi Sulastri, Muhammad Sulaiman Zubair, Ronny Lesmana, Ahmed Fouad Abdelwahab Mohammed, Nasrul Wathoni

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Evi SulastriDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.ORCID 0000-0001-5785-4566
Muhammad Sulaiman ZubairDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Tadulako, Palu, 94119, Indonesia.
Ronny LesmanaDepartment of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Ahmed Fouad Abdelwahab MohammedDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Nasrul WathoniDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.ORCID 0000-0002-5985-6909
Padjadjaran University · IDTadulako University · IDMinia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUlvan is a natural polymer and type of sulfated polysaccharides from green seaweed that could have potential as a candidate for wound dressing material based on the support of its biopolymer characteristics such as antioxidant and antimicrobial activities.

objectiveIn this study, we developed and prepared three different hydrogel films to explore the potency of ulvan for wound dressing application.

methodsUlvan hydrogel films were prepared by the facile method through ionic crosslinking with boric acid and added glycerol as a plasticizer. The films were evaluated in regard to swelling degree, water vapor transmission (WVTR), Fourier transform infrared (FTIR), powder x-ray diffractometry (P-XRD), scanning electron microscopy (SEM), mechanical properties, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), antimicrobial, and antioxidant activity.

resultsThe hydrogel films showed that the different concentration of ulvan in the formula affects the characteristics of the hydrogel film. The higher the concentration of ulvan in UHF, the higher the value of viscosity (201±13.45 to 689±62.23 cps for UHF5 to UHF10), swelling degree (82% to 130% for UHF5 to UHF10 at 1 h), moisture content (24%±1.94% to 18.4%±0.51 for UHF5 to UHF10), and the WVTR were obtained in the range 1856-2590g/m

conclusionThe swelling behavior and WVTR of these films are great and could have potential as a wound dressing biomaterial, supported by their antimicrobial and antioxidant properties.

Indexed as

BandagesAnti-Bacterial AgentsAntioxidantsBoric AcidsChemistry, PharmaceuticalCross-Linking ReagentsGlycerolGram-Negative BacteriaGram-Positive BacteriaHydrogelsPlasticizersPolysaccharidesViscosityWound HealingAnti-Bacterial AgentsAntioxidantsboric acidBoric AcidsCross-Linking ReagentsGlycerolHydrogelsPlasticizersPolysaccharidesulvanantimicrobialantioxidanthydrogel filmsulvanwound dressing

Identifiers

PMID34675484
PMCPMC8502111
OpenAlexW3203549324

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.