Evidence map›Paper›PMID 34675475›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2021

Short-Term Outcomes After COVID-19-Related Treatment Interruption Among Patients with Neovascular Age-Related Macular Degeneration Receiving Intravitreal Bevacizumab.

Davide Allegrini, Raffaele Raimondi, Giovanni Montesano, Alfredo Borgia, Tania Sorrentino, Panagiotis Tsoutsanis, Mario R Romano

Abstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Genome-Wide Pleiotropy Study Identifies Association ofJournal of clinical medicine · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Davide AllegriniEye Center, Humanitas, Bergamo, Italy.ORCID 0000-0002-5988-706X
Raffaele RaimondiDepartment of Biomedical Sciences, Humanitas University, Milano, Italy.
Giovanni MontesanoUniversity of London - Optometry and Visual Sciences, London, UK.
Alfredo BorgiaDepartment of Biomedical Sciences, Humanitas University, Milano, Italy.
Tania SorrentinoDepartment of Biomedical Sciences, Humanitas University, Milano, Italy.
Panagiotis TsoutsanisDepartment of Biomedical Sciences, Humanitas University, Milano, Italy.
Mario R RomanoEye Center, Humanitas, Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess outcomes and recovery strategy of patients undergoing intravitreal injections for exudative age-related macular degeneration who experienced COVID-19 related interruption in treatment during complete lockdown.

methodsThis was a retrospective, observational case study. We used a mixed effect model with random intercepts to evaluate best corrected visual acuity (BCVA) accounting for measured central macular thickness (CMT) and individual variability of each eye. Furthermore, we analysed measures of the pigmented epithelium detachment as well as presence of subretinal fluid and intraretinal cysts.

resultsWe included 39 patients and we found a significant reduction in the BCVA between the pre- and post-lockdown controlling for CMT. There was no significant difference in pigmented epithelium detachment and in presence of subretinal fluid and intraretinal cysts.

conclusionWe detected a significant loss in visual function. The magnitude of the average loss was, however, limited suggesting good efficacy of the recovery strategy.

Indexed as

bevacizumabcovid-19intravitreal injectionIVT interruption

Identifiers

PMID34675475
PMCPMC8517983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.