Evidence map›Paper›PMID 34675469›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2021

The Retinal Posterior Pole in Early Parkinson's Disease: A Fundus Perimetry and SD-OCT Study.

Massimo Cesareo, Ernesto Di Marco, Clarissa Giannini, Matteo Di Marino, Francesco Aiello, Antonio Pisani, Mariangela Pierantozzi, Nicola Biagio Mercuri, Carlo Nucci, Raffaele Mancino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Dynamics of retinal changes in early-stage Parkinson's disease.Acta neuropathologica communications · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Massimo CesareoOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Ernesto Di MarcoOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-6477-7690
Clarissa GianniniOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Matteo Di MarinoOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0001-6926-9655
Francesco AielloOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Antonio PisaniDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Mariangela PierantozziParkinson's Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Nicola Biagio MercuriNeurology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Carlo NucciOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Raffaele MancinoOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
University of Rome Tor Vergata · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the structure and function of the retinal posterior pole in patients with early Parkinson's disease (PD) and to identify possible biomarkers correlated with clinical features. PATIENTS AND

methodsA cross-sectional case-control study of 21 patients with PD and 22 age-matched healthy controls (HC) was conducted. All subjects underwent full ophthalmological examinations, fundus perimetry (FP) and spectral domain-OCT (SD-OCT) of the entire retinal posterior pole and peripapillary retinal nerve fiber layer (pRNFL).

resultsWe analyzed 41 eyes from 21 patients (14 males and 7 females) with early PD (Hoehn and Yahr scale (H&Y) equal to or less than stage 2) and 41 eyes from 22 HC (12 males and 10 females). We found no significant difference in the pRNFL thickness between patients with PD and HC. The statistical analysis of the SD-OCT posterior pole area, consisting of 64 values for each retinal layer, revealed a decrease in the outer nuclear layer (ONL) thickness in patients with PD (p < 0.0001). On the contrary, a significant increase in the thickness of the outer plexiform layer (OPL) (p < 0.0001) and of the retinal pigmented epithelium (RPE) (p= 0.002) compared to healthy controls was detected. Other retinal layers showed no significant statistical differences. The differential light sensitivity (DLS) values measured by FP were significantly lower in patients than the healthy controls (15 [13-16.2] vs 17.95 [16.08-18.96] p<0.0001).

conclusionOur results showed that DLS and retinal structure differed in the posterior pole between patients with early PD and controls. Thickening of the OPL may represent accumulation of α-synuclein in the OPL of patients with PD.

Indexed as

alpha-synucleindopamineoptical coherence tomographyParkinson’s diseaseretina

Identifiers

PMID34675469
PMCPMC8500491
OpenAlexW3203140695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.