ArticleCommunications biology2021
Electrocorticography reveals thalamic control of cortical dynamics following traumatic brain injury.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Fast and Slow Recovery of Consciousness Following Traumatic Brain Injury.Neurocritical care · 2026Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- rTMS combined with median nerve magnetic stimulation for prolonged disorders of consciousness following intracerebral hemorrhage: a randomized controlled trial protocol.Frontiers in neurology · 2025Article
- [Current progress on characteristics of intracranial electrophysiology related to prolonged disorders of consciousness].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Sleep-like cortical dynamics during wakefulness and their network effects following brain injury.Nature communications · 2024Review
- Brain-Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap.Neurocritical care · 2024Review
- Return of intracranial beta oscillations and traveling waves with recovery from traumatic brain injury.bioRxiv : the preprint server for biology · 2024Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- Modeling the role of the thalamus in resting-state functional connectivity: Nature or structure.PLoS computational biology · 2023Article
- Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.Brain : a journal of neurology · 2023Article
- Brain Circuitry of Consciousness: A Review of Current Models and a Novel Synergistic Model With Clinical Application.Neurosurgery practice · 2023Article
- Use of magnetic source imaging to assess recovery after severe traumatic brain injury-an MEG pilot study.Frontiers in neurology · 2023Article
- Microscale multicircuit brain stimulation: Achieving real-time brain state control for novel applications.Current research in neurobiology · 2023Review
- In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments.Frontiers in neuroscience · 2023Article
- EEG Evidence Reveals Zolpidem-Related Alterations and Prognostic Value in Disorders of Consciousness.Frontiers in neuroscience · 2022Article
- Seizing the Future: Predicting Epilepsy After TBI.Epilepsy currentsArticle
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Authors and funding
11 authors.
Funding
Abstract
The return of consciousness after traumatic brain injury (TBI) is associated with restoring complex cortical dynamics; however, it is unclear what interactions govern these complex dynamics. Here, we set out to uncover the mechanism underlying the return of consciousness by measuring local field potentials (LFP) using invasive electrophysiological recordings in patients recovering from TBI. We found that injury to the thalamus, and its efferent projections, on MRI were associated with repetitive and low complexity LFP signals from a highly structured phase space, resembling a low-dimensional ring attractor. But why do thalamic injuries in TBI patients result in a cortical attractor? We built a simplified thalamocortical model, which connotes that thalamic input facilitates the formation of cortical ensembles required for the return of cognitive function and the content of consciousness. These observations collectively support the view that thalamic input to the cortex enables rich cortical dynamics associated with consciousness.
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