Evidence map›Paper›PMID 34675286›Full record

ArticleScientific reports2021

Thermodynamic stability, in-vitro permeability, and in-silico molecular modeling of the optimal Elaeis guineensis leaves extract water-in-oil nanoemulsion.

Nissha Bharrathi Romes, Roswanira Abdul Wahab, Mariani Abdul Hamid, Habeebat Adekilekun Oyewusi, Nurul Huda, Rovina Kobun

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Nanoemulsions in Skin Cancer Therapy: A Promising Frontier.Current pharmaceutical biotechnology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Protective Effects of Berberine-Loaded Black Seed (Iranian journal of pharmaceutical research : IJPR
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nissha Bharrathi RomesDepartment of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor, Bahru, Malaysia.
Roswanira Abdul WahabDepartment of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor, Bahru, Malaysia. roswanira@kimia.fs.utm.my.ORCID http://orcid.org/0000-0002-9982-6587
Mariani Abdul HamidSchool of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor, Bahru, Malaysia.
Habeebat Adekilekun OyewusiDepartment of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor, Bahru, Malaysia.
Nurul HudaFaculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu, 88400, Sabah, Malaysia. drnurulhuda@ums.edu.my.ORCID http://orcid.org/0000-0001-9867-6401
Rovina KobunFaculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu, 88400, Sabah, Malaysia.
University of Technology Malaysia · MYUniversiti of Malaysia Sabah · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoemulsion is a delivery system used to enhance bioavailability of plant-based compounds across the stratum corneum. Elaeis guineensis leaves are rich source of polyphenolic antioxidants, viz. gallic acid and catechin. The optimal E. guineensis leaves extract water-in-oil nanoemulsion was stable against coalescence, but it was under significant influence of Ostwald ripening over 90 days at 25 °C. The in-vitro permeability revealed a controlled and sustained release of the total phenolic compounds (TPC) of EgLE with a cumulative amount of 1935.0 ± 45.7 µgcm

Indexed as

Administration, CutaneousArecaceaeEmulsionsHumansModels, MolecularPermeabilityPlant ExtractsPlant LeavesSkinSkin AbsorptionThermodynamicsWaterEmulsionsPlant ExtractsWater

Identifiers

PMID34675286
PMCPMC8531315
OpenAlexW3205490462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.