Evidence map›Paper›PMID 34675280›Full record

ArticleScientific reports2021

Sex-differences in COVID-19 associated excess mortality is not exceptional for the COVID-19 pandemic.

Jens Nielsen, Sarah K Nørgaard, Giampaolo Lanzieri, Lasse S Vestergaard, Kaare Moelbak

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Paid and unpaid productivity losses across 28 European countries due to excess deaths and COVID-19 deaths from 2020 to 2023.The European journal of health economics : HEPAC : health economics in prevention and care · 2026
    Article
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  6. Observational
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  10. The Impact of Long COVID on the Quality of Life.Medicina (Kaunas, Lithuania) · 2024
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jens NielsenInfectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark. nls@ssi.dk.
Sarah K NørgaardInfectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
Giampaolo LanzieriStatistical Office of the European Union (Eurostat), Population and Migration Unit, Luxembourg, Luxembourg.
Lasse S VestergaardInfectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
Kaare MoelbakInfectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Europe experienced excess mortality from February through June, 2020 due to the COVID-19 pandemic, with more COVID-19-associated deaths in males compared to females. However, a difference in excess mortality among females compared to among males may be a more general phenomenon, and should be investigated in none-COVID-19 situations as well. Based on death counts from Eurostat, separate excess mortalities were estimated for each of the sexes using the EuroMOMO model. Sex-differential excess mortality were expressed as differences in excess mortality incidence rates between the sexes. A general relation between sex-differential and overall excess mortality both during the COVID-19 pandemic and in preceding seasons were investigated. Data from 27 European countries were included, covering the seasons 2016/17 to 2019/20. In periods with increased excess mortality, excess was consistently highest among males. From February through May 2020 male excess mortality was 52.7 (95% PI: 56.29; 49.05) deaths per 100,000 person years higher than for females. Increased male excess mortality compared to female was also observed in the seasons 2016/17 to 2018/19. We found a linear relation between sex-differences in excess mortality and overall excess mortality, i.e., 40 additional deaths among males per 100 excess deaths per 100,000 population. This corresponds to an overall female/male mortality incidence ratio of 0.7. In situations with overall excess mortality, excess mortality increases more for males than females. We suggest that the sex-differences observed during the COVID-19 pandemic reflects a general sex-disparity in excess mortality.

Indexed as

Sex FactorsAdolescentAdultAgedAged, 80 and overAlgorithmsChildChild, PreschoolCOVID-19EuropeFemaleHumansIncidenceInfantInfant, NewbornMale

Identifiers

PMID34675280
PMCPMC8531278

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.