Evidence map›Paper›PMID 34675263›Full record

ArticleScientific reports2021

DNA damage response of haematopoietic stem and progenitor cells to high-LET neutron irradiation.

Monique Engelbrecht, Roya Ndimba, Maryna de Kock, Xanthene Miles, Shankari Nair, Randall Fisher, Peter du Plessis, Julie Bolcaen, Matthys Hendrik Botha, Elbie Zwanepoel and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Monique EngelbrechtDepartment of Medical Bioscience, University of the Western Cape, Faculty of Science, Robert Sobukwe Road, Bellville, Cape Town, 7535, South Africa. mengelbrecht@tlabs.ac.za.
Roya NdimbaNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Maryna de KockDepartment of Medical Bioscience, University of the Western Cape, Faculty of Science, Robert Sobukwe Road, Bellville, Cape Town, 7535, South Africa.
Xanthene MilesNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Shankari NairNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Randall FisherNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Peter du PlessisNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Julie BolcaenNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Matthys Hendrik BothaDepartment of Obstetrics and Gynaecology, Stellenbosch University, Faculty of Medicine and Health Sciences, Clinical Building, Francie van Zijl Drive, Parow Valley, Cape Town, 7500, South Africa.
Elbie ZwanepoelDepartment of Obstetrics and Gynaecology, Karl Bremer Hospital, Frans Conradie Drive, Bellville, 7530, South Africa.
Simon SioenRadiobiology, Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Gent, Belgium.
Ans BaeyensRadiobiology, Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Gent, Belgium.
Jaime Nieto-CameroNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Evan de KockNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa.
Charlot VandevoordeNuclear Medicine Department, Radiation Biophysics Division, NRF-iThemba LABS, Old Faure Road, Faure, Cape Town, 7131, South Africa. cvandevoorde@tlabs.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The radiosensitivity of haematopoietic stem and progenitor cells (HSPCs) to neutron radiation remains largely underexplored, notwithstanding their potential role as target cells for radiation-induced leukemogenesis. New insights are required for radiation protection purposes, particularly for aviation, space missions, nuclear accidents and even particle therapy. In this study, HSPCs (CD34

Indexed as

Cells, CulturedDNA DamageDNA RepairDose-Response Relationship, RadiationHematopoietic Stem CellsHumansLinear Energy TransferMicronucleus TestsNeutrons

Identifiers

PMID34675263
PMCPMC8531011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.