ArticleJournal of neurointerventional surgery2022
Histopathological analysis of in vivo specimens of recurrent aneurysms after coil embolization.
Article in Journal of neurointerventional surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Dome-remnant dissociation after coil embolization of a basilar tip aneurysm: serial MR cisternography, silent MRA, and computational fluid dynamics findings suggest early hemodynamic redistribution. Illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Microsurgical clipping for coil-extruded recurrent aneurysms: Case series and technical pearls.Surgical neurology international · 2026Article
- Human neural stem cell-derived exosomes promote functional recovery in subarachnoid hemorrhage via bdnf/trkb pathway activation and astrocyte modulation.Acta neuropathologica communications · 2025Article
- Circumferential Aneurysm Wall Enhancement Predicts Recanalization After Stent-Assisted Coiling in Small Unruptured Intracranial Aneurysms.Brain and behavior · 2025Article
- Article
- Letter to the Editor. Coil embolization complications linked to aneurysmal inflammation.Journal of neurosurgery. Case lessons · 2024Article
- Outcomes of reconstructive endovascular treatment of vertebrobasilar dissecting aneurysms with intramural hematoma.Frontiers in neurology · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAneurysm recurrence after coil embolization remains a challenging problem.
objectiveTo determine the histopathological features of recurrent aneurysm specimens and explore the mechanism of aneurysm recurrence.
methodsNine aneurysm specimens were collected from eight patients who underwent clipping for aneurysm recurrence within 2 years after embolization. All specimens were sectioned and embedded in resin, stained with hematoxylin-eosin (H&E), Masson stain, and immunohistochemical staining for smooth muscle actin (SMA) and CD68+ antibodies, and were examined under light microscopy.
resultsFive aneurysms were surgically clipped owing to post-embolic subarachnoid hemorrhage, while the other four aneurysms had dangerous recanalization detected on follow-up imaging. Five aneurysms had self-growth and four aneurysms had coil compactions. Gross observation showed that each recurrent aneurysm was wrapped by a thrombus and the aneurysm wall; some coils protruded from the pseudocapsule in some ruptured aneurysms. Microscopically, H&E staining showed that three types of thrombi (fresh thrombus, granulation tissue, and scar tissue) coexisted in one section. In addition, characteristic unstable and unorganized thrombi with empty spaces were found in the neck cavity. Immunohistochemical staining showed that the SMA stain was discontinued and incomplete, and CD68+ antibody and H&E staining revealed inflammatory infiltrate in the aneurysm wall.
conclusionThe coexistence of three types of thrombi is the main characteristic of recurrent aneurysms. The formation of stable thrombus may be one of the key points of aneurysm recurrence. Smooth muscle cell damage and infiltration of inflammatory cells in the aneurysm wall probably contribute to the recanalization.
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