Evidence map›Paper›PMID 34675097›Full record

ArticleNeurology2022

Bilateral Structural Network Abnormalities in Epilepsy Associated With Bottom-of-Sulcus Dysplasia.

Remika Mito, David N Vaughan, Mira Semmelroch, Alan Connelly, Graeme D Jackson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Remika MitoFrom the Florey Institute of Neuroscience and Mental Health (R.M., D.N.V., M.S., A.C., G.D.J.), Heidelberg; Florey Department of Neuroscience and Mental Health (D.N.V., A.C., G.D.J.), University of Melbourne; and Department of Neurology (D.N.V., G.D.J.), Austin Health, Heidelberg, Australia. remika.mito@florey.edu.au.
David N VaughanFrom the Florey Institute of Neuroscience and Mental Health (R.M., D.N.V., M.S., A.C., G.D.J.), Heidelberg; Florey Department of Neuroscience and Mental Health (D.N.V., A.C., G.D.J.), University of Melbourne; and Department of Neurology (D.N.V., G.D.J.), Austin Health, Heidelberg, Australia.ORCID 0000-0002-6225-7739
Mira SemmelrochFrom the Florey Institute of Neuroscience and Mental Health (R.M., D.N.V., M.S., A.C., G.D.J.), Heidelberg; Florey Department of Neuroscience and Mental Health (D.N.V., A.C., G.D.J.), University of Melbourne; and Department of Neurology (D.N.V., G.D.J.), Austin Health, Heidelberg, Australia.ORCID 0000-0002-9660-775X
Alan ConnellyFrom the Florey Institute of Neuroscience and Mental Health (R.M., D.N.V., M.S., A.C., G.D.J.), Heidelberg; Florey Department of Neuroscience and Mental Health (D.N.V., A.C., G.D.J.), University of Melbourne; and Department of Neurology (D.N.V., G.D.J.), Austin Health, Heidelberg, Australia.
Graeme D JacksonFrom the Florey Institute of Neuroscience and Mental Health (R.M., D.N.V., M.S., A.C., G.D.J.), Heidelberg; Florey Department of Neuroscience and Mental Health (D.N.V., A.C., G.D.J.), University of Melbourne; and Department of Neurology (D.N.V., G.D.J.), Austin Health, Heidelberg, Australia.
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTo identify white matter fiber tracts that exhibit structural abnormality in patients with bottom-of-sulcus dysplasia (BOSD) and investigate their association with seizure activity.

methodsWhole-brain fixel-based analysis of diffusion MRI data was performed to identify white matter fiber tracts with significant reductions in fiber density and cross-section in patients with BOSD (n = 20) when compared to healthy control participants (n = 40). Results from whole-brain analysis were used to investigate the association of fiber tract abnormality with seizure frequency and epilepsy duration.

resultsDespite the focal nature of the dysplasia, patients with BOSD showed widespread abnormality in white matter fiber tracts, including the bilateral corticospinal, corticothalamic, and cerebellothalamic tracts, superior longitudinal fasciculi, corpus callosum (body), and the forceps major. This pattern of bilateral connectivity reduction was not related to the laterality of the lesion. Exploratory post hoc analyses showed that high seizure frequency was associated with greater reduction in fiber density at the forceps major, bilateral corticospinal, and cerebellothalamic tracts. DISCUSSION: We demonstrate evidence of a bilaterally distributed, specific white matter network that is vulnerable to disruption in BOSD. The degree of tract abnormality is partly related to seizure activity, but additional contributors such as the genetic background and effects of treatment or environment have not been excluded.

Indexed as

EpilepsyWhite MatterCorpus CallosumDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumans

Identifiers

PMID34675097
PMCPMC8762587
OpenAlexW3207086699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.