Evidence map›Paper›PMID 34675088›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior.

Rodrigo S Carraro, Guilherme A Nogueira, Davi Sidarta-Oliveira, Rodrigo S Gaspar, Nathalia R Dragano, Joseane Morari, Vanessa C D Bobbo, Eliana P Araujo, Natalia F Mendes, Ariane M Zanesco and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Rodrigo S CarraroLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Guilherme A NogueiraLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Davi Sidarta-OliveiraLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Rodrigo S GasparLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Nathalia R DraganoLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Joseane MorariLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Vanessa C D BobboLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Eliana P AraujoLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Natalia F MendesLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Ariane M ZanescoLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Natalia TobarNuclear Medicine Service, Department of Radiology, Hospital of Clinics, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Celso D RamosNuclear Medicine Service, Department of Radiology, Hospital of Clinics, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
Jéssica M ToscaroBrazilian Center for Research in Energy and Materials, Brazilian Biosciences National Laboratory, Campinas, 13083-970, Sao Paulo, Brazil.
Marcio C BajgelmanBrazilian Center for Research in Energy and Materials, Brazilian Biosciences National Laboratory, Campinas, 13083-970, Sao Paulo, Brazil.
Licio A VellosoLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil lavellos@unicamp.br.ORCID 0000-0002-4806-7218
Universidade Estadual de Campinas (UNICAMP) · BRBrazilian Center for Research in Energy and Materials · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nescient helix-loop-helix 2 (NHLH2) is a hypothalamic transcription factor that controls the expression of prohormone convertase 1/3, therefore having an impact on the processing of proopiomelanocortin and thus on energy homeostasis. Studies have shown that KO of

Indexed as

AnimalsAnxietyArcuate Nucleus of HypothalamusBasic Helix-Loop-Helix ProteinsBody Mass IndexDepressionDiet, High-FatFemaleMaleMiceObesityBasic Helix-Loop-Helix ProteinsNhlh2 protein, mouseenergy expenditurefood intakeinsulinleptin

Identifiers

PMID34675088
PMCPMC8638695
OpenAlexW3205357939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.