ArticleProceedings of the National Academy of Sciences of the United States of America2021
A rapidly reversible mutation generates subclonal genetic diversity and unstable drug resistance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Genetic and Epigenetic Mechanisms Underlying Reversible Adaptive Responses in Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- Disruption and adaptation: infant gut microbiota's dynamic response to SARS-CoV-2 infection.Microbiome · 2025Article
- Article
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Authors and funding
8 authors.
Funding
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Abstract
Most genetic changes have negligible reversion rates. As most mutations that confer resistance to an adverse condition (e.g., drug treatment) also confer a growth defect in its absence, it is challenging for cells to genetically adapt to transient environmental changes. Here, we identify a set of rapidly reversible drug-resistance mutations in
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Registered trials
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