Evidence map›Paper›PMID 34674997›Full record

ArticleAJNR. American journal of neuroradiology2021

Changes in Ventricular and Cortical Volumes following Shunt Placement in Patients with Idiopathic Normal Pressure Hydrocephalus.

P M Cogswell, M C Murphy, M L Senjem, H Botha, J L Gunter, B D Elder, J Graff-Radford, D T Jones, J K Cutsforth-Gregory, C G Schwarz and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

P M CogswellFrom the Departments of Radiology (P.M.C., M.C.M., J.L.G., C.G.S., J.H., C.R.J.) Cogswell.petrice@mayo.edu.ORCID 0000-0002-8128-4476
M C MurphyFrom the Departments of Radiology (P.M.C., M.C.M., J.L.G., C.G.S., J.H., C.R.J.).ORCID 0000-0002-3766-0518
M L SenjemInformation Technology (M.L.S.).ORCID 0000-0001-9308-9275
H BothaNeurology (H.B., J.G.-R., D.T.J., J.K.C.-G.).ORCID 0000-0003-4390-685X
J L GunterFrom the Departments of Radiology (P.M.C., M.C.M., J.L.G., C.G.S., J.H., C.R.J.).ORCID 0000-0001-7813-9078
B D ElderNeurosurgery (B.D.E., F.B.M.).ORCID 0000-0002-7782-7829
J Graff-RadfordNeurology (H.B., J.G.-R., D.T.J., J.K.C.-G.).ORCID 0000-0003-2770-0691
D T JonesNeurology (H.B., J.G.-R., D.T.J., J.K.C.-G.).ORCID 0000-0002-4807-9833
J K Cutsforth-GregoryNeurology (H.B., J.G.-R., D.T.J., J.K.C.-G.).ORCID 0000-0002-5689-4424
C G SchwarzFrom the Departments of Radiology (P.M.C., M.C.M., J.L.G., C.G.S., J.H., C.R.J.).ORCID 0000-0002-1466-8357
F B MeyerNeurosurgery (B.D.E., F.B.M.).ORCID 0000-0002-4310-7962
J HustonFrom the Departments of Radiology (P.M.C., M.C.M., J.L.G., C.G.S., J.H., C.R.J.).ORCID 0000-0003-0584-9460
C R JackFrom the Departments of Radiology (P.M.C., M.C.M., J.L.G., C.G.S., J.H., C.R.J.).ORCID 0000-0001-7916-622X
Mahindra and Mahindra Limited (India) · INJacobson Holman (United States) · USInformation Technology Laboratory · USMACOM (United States) · USMayo Clinic · USNeurology, Inc · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWhile changes in ventricular and extraventricular CSF spaces have been studied following shunt placement in patients with idiopathic normal pressure hydrocephalus, regional changes in cortical volumes have not. These changes are important to better inform disease pathophysiology and evaluation for copathology. The purpose of this work is to investigate changes in ventricular and cortical volumes in patients with idiopathic normal pressure hydrocephalus following ventriculoperitoneal shunt placement. MATERIALS AND

methodsThis is a retrospective cohort study of patients with idiopathic normal pressure hydrocephalus who underwent 3D T1-weighted MR imaging before and after ventriculoperitoneal shunt placement. Images were analyzed using tensor-based morphometry with symmetric normalization to determine the percentage change in ventricular and regional cortical volumes. Ventricular volume changes were assessed using the Wilcoxon signed rank test, and cortical volume changes, using a linear mixed-effects model (

resultsThe study included 22 patients (5 women/17 men; mean age, 73 [SD, 6] years). Ventricular volume decreased after shunt placement with a mean change of -15.4% (

conclusionsOverall, cortical volumes mildly increased after shunt placement in patients with idiopathic normal pressure hydrocephalus with the greatest increases in regions near the vertex, indicating postshunt decompression of the cortex and sulci. Ventricular volumes showed an expected decrease after shunt placement.

Indexed as

HydrocephalusHydrocephalus, Normal PressureAgedFemaleHumansMagnetic Resonance ImagingMaleRetrospective StudiesTreatment OutcomeVentriculoperitoneal Shunt

Identifiers

PMID34674997
PMCPMC8805754
OpenAlexW3205458285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.