Evidence map›Paper›PMID 34674774›Full record

SynthesisInfectious diseases of poverty2021

Diagnostic value of chest computed tomography imaging for COVID-19 based on reverse transcription-polymerase chain reaction: a meta-analysis.

Jing Liu, Xue Yang, Yunxian Zhu, Yi Zhu, Jingzhe Liu, Xiantao Zeng, Hongjun Li

Abstract readMeta-Analysis
In one paragraph

Synthesis in Infectious diseases of poverty, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing LiuDepartment of Radiology, The Affiliated Infectious Diseases Hospital of Soochow University, The Fifth People's Hospital of Suzhou, Suzhou, 215000, Jiangsu, People's Republic of China.
Xue YangDepartment of Radiology, Beijing Youan Hospital Capital Medical University, Beijing, 100069, People's Republic of China.
Yunxian ZhuDepartment of Radiology, The Affiliated Infectious Diseases Hospital of Soochow University, The Fifth People's Hospital of Suzhou, Suzhou, 215000, Jiangsu, People's Republic of China.
Yi ZhuDepartment of Radiology, The Affiliated Infectious Diseases Hospital of Soochow University, The Fifth People's Hospital of Suzhou, Suzhou, 215000, Jiangsu, People's Republic of China.
Jingzhe LiuDepartment of Radiology, The First Hospital of Tsinghua University, Beijing, 100016, People's Republic of China.
Xiantao ZengCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, People's Republic of China.
Hongjun LiDepartment of Radiology, Beijing Youan Hospital Capital Medical University, Beijing, 100069, People's Republic of China. lihongjun00113@ccmu.edu.cn.

Funding

beijing municipal health commission, technology achievements and appropriate technology promotion project 2020-TG-002national key research and development program of ministry of science and technology SQ2019YFE013267national natural science foundation of china 61936013national natural science foundation of china 81771806you'an medical development project of covid-19 emergency prevention and control public BJYAYY-2020YC-03
6 · The paper itself

Abstract

backgroundThe computed tomography (CT) diagnostic value of COVID-19 is controversial. We summarized the value of chest CT in the diagnosis of COVID-19 through a meta-analysis based on the reference standard.

methodsAll Chinese and English studies related to the diagnostic value of CT for COVID-19 across multiple publication platforms, was searched for and collected. Studies quality evaluation and plotting the risk of bias were estimated. A heterogeneity test and meta-analysis, including plotting sensitivity (Sen), specificity (Spe) forest plots, pooled positive likelihood ratio (+LR), negative likelihood ratio (-LR), dignostic odds ratio (DOR) values and 95% confidence interval (CI), were estimated. If there was a threshold effect, summary receiver operating characteristic curves (SROC) was further plotted. Pooled area under the receiver operating characteristic curve (AUROC) and 95% CI were also calculated.

resultsTwenty diagnostic studies that represented a total of 9004 patients were included from 20 pieces of literatures after assessing all the aggregated studies. The reason for heterogeneity was caused by the threshold effect, so the AUROC = 0.91 (95% CI: 0.89-0.94) for chest CT of COVID-19. Pooled sensitivity, specificity, +LR, -LR from 20 studies were 0.91 (95% CI: 0.88-0.94), 0.71 (95% CI: 0.59-0.80), 3.1(95% CI: 2.2-4.4), 0.12 (95% CI: 0.09-0.17), separately. The I

conclusionsThe results of this study showed that CT diagnosis of COVID-19 was close to the reference standard. The diagnostic value of chest CT may be further enhanced if there is a unified COVID-19 diagnostic standard. However, please pay attention to rational use of CT.

Indexed as

COVID-19ThoraxTomography, X-Ray ComputedHumansReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityCOVID-19Reference standardTomographyX-ray computed

Identifiers

PMID34674774
PMCPMC8529575

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.