Trial reportCritical care (London, England)2021
Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature.
Trial report in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01187134 (Medical Education for Sepsis Source Control and Antibiotics), which is not on this map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Medical Education for Sepsis Source Control and Antibiotics
Who cites it
38 citing papers in PubMed, 63 citations in OpenAlex.
- [Stress, allostasis and organ failure : On the 90th anniversary of the first description of the "general adaptation syndrome"].Die Anaesthesiologie · 2026Review
- The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation.Brain, behavior, & immunity - health · 2026Review
- Continuous Temperature Monitoring via Wearable Devices for Fever or Infection Management in Acute Care Hospitals: Scoping Review of Clinical Implementation and Data Analytics.JMIR mHealth and uHealth · 2026Article
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial.Annals of intensive care · 2026Article
- Temperature Trajectories Are Associated With the Prognosis of Septic Patients.Emergency medicine international · 2026Article
- Bridging sepsis physiology and biosensor engineering: a clinical perspective on electrochemical cytokine sensor design.Frontiers in bioengineering and biotechnology · 2026Article
- Body temperature as a dynamic host-response biomarker in sepsis: trajectories and time-varying mortality risk.Frontiers in cellular and infection microbiology · 2026Article
- Hypothermia association with all-cause mortality in critically ill patients with sepsis based on the MIMIC-IV database.Scientific reports · 2025Article
- [Inflammatory phenotypes in sepsis and the role of vitamin C on the corresponding phenotypes].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Sepsis in the absence of fever: Determining the criteria for and feasibility of future therapeutic temperature management trials.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Development of a nomogram to predict 30-day mortality in patients with chronic obstructive pulmonary disease complicated by sepsis: insights from the Medical Information Mart for Intensive Care (MIMIC-IV) database.Journal of thoracic disease · 2025Article
- Association of Carboxyhemoglobin With Severity and Outcomes in Hypothermic Patients: A Retrospective Cohort Study.Cureus · 2025Article
- Fever in Sepsis Revisited: Is a Little Heat What We Need?Open forum infectious diseases · 2025Review
- Clinical characteristics associated with septic shock complicating hypothermia: a retrospective cohort study from the MIMIC-IV database.European journal of medical research · 2025Article
- Early body temperature trajectories and short term prognosis in sepsis associated acute kidney injury.Scientific reports · 2025Article
- Intelligent Prediction Platform for Sepsis Risk Based on Real-Time Dynamic Temporal Features: Design Study.JMIR medical informatics · 2025Article
- Evaluation of Presepsin for Early Diagnosis of Sepsis in the Emergency Department.Journal of clinical medicine · 2025Article
- Unique infrared thermographic profiles and altered hypothalamic neurochemistry associated with mortality in endotoxic shock.Experimental neurology · 2025Article
- Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundFever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.
methodsWe did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia.
resultsWith 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever.
conclusionsSeptic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.