Evidence map›Paper›PMID 34674716›Full record

ArticleBMC veterinary research2021

Changes in the gut microbiota diversity of brown frogs (Rana dybowskii) after an antibiotic bath.

Qing Tong, Li-Yong Cui, Jia Bie, Xiao-Yun Han, Zong-Fu Hu, Hong-Bin Wang, Jian-Tao Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qing TongCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Li-Yong CuiJiamusi Branch of Heilongjiang Academy of Forestry Sciences, Jiamusi, 154002, China.
Jia BieCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Xiao-Yun HanCollege of Life Science, Jiamusi University, Jiamusi, 154007, China.
Zong-Fu HuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Hong-Bin WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Jian-Tao ZhangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. zhangjiantao@neau.edu.cn.
Northeast Agricultural University · CNJiamusi University · CNHeilongjiang Academy of Forestry · CN

Funding

National Key R&D Program of China 2017YFD0501000Scientific Research Projects of Basic Scientific Research Business Expresses of Colleges and University in Heilongjiang Province (2020-KYYWF-0231)
6 · The paper itself

Abstract

backgroundCaptive amphibians frequently receive antibiotic baths to control bacterial diseases. The potential collateral effect of these antibiotics on the microbiota of frogs is largely unknown. To date, studies have mainly relied on oral administration to examine the effects of antibiotics on the gut microbiota; in contrast, little is known regarding the effects of bath-applied antibiotics on the gut microbiota. The gut microbiota compositions of the gentamicin, recovery, and control groups were compared by Illumina high-throughput sequencing, and the functional profiles were analysed using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). Furthermore, the relationship between the structure and predicted functional composition of the gut microbiota was determined.

resultsThe alpha diversity indices were significantly reduced by the gentamicin bath, illustrating that this treatment significantly changed the composition of the gut microbiota. After 7 days, the gut microbiota of the recovery group was not significantly different from that of the gentamicin group. Forty-four indicator taxa were selected at the genus level, comprising 42 indicators representing the control group and 2 indicators representing the gentamicin and recovery groups. Potential pathogenic bacteria of the genera Aeromonas, Citrobacter, and Chryseobacterium were significantly depleted after the gentamicin bath. There was no significant positive association between the community composition and functional composition of the gut microbiota in the gentamicin or control frogs, indicating that the functional redundancy of the gut bacterial community was high.

conclusionsGentamicin significantly changed the structure of the gut microbiota of R. dybowskii, and the gut microbiota exhibited weak resilience. However, the gentamicin bath did not change the functional composition of the gut microbiota of R. dybowskii, and there was no significant correlation between the structural composition and the functional composition of the gut microbiota.

Indexed as

Administration, TopicalAnimalsAnti-Bacterial AgentsBacteriaGastrointestinal MicrobiomeGentamicinsRanidaeAnti-Bacterial AgentsGentamicinsAntimicrobial bathBacterial communityFunctional predictionGentamicinHigh-throughput sequencing

Identifiers

PMID34674716
PMCPMC8529755
OpenAlexW3206793613

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.