ArticleBMC medicine2021
Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank.
Article in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Intra-Pancreatic Fat Deposition Versus Hepatic Fat in Relation to Incident Heart Failure: A Prospective Cohort Analysis.Reviews in cardiovascular medicine · 2026Article
- Association of maternal cardiovascular health in early-to-mid pregnancy with offspring cardiovascular phenotypes in early childhood: a prospective birth cohort study.Pediatric research · 2026Article
- Shifts in socioeconomic status alter cardiovascular disease risk and mortality through modulating Life's Crucial 9: a prospective cohort study of UK Biobank participants.BMJ public health · 2026Article
- Lactation duration and ischemic heart disease among parous postmenopausal females from a prospective cohort study.Communications medicine · 2025Article
- Association of Life's Essential 8 with incidence of heart failure modified by depressive symptoms: a prospective cohort study from UK Biobank.BMC medicine · 2025Article
- Choline Metabolites, Genetic Susceptibility, and Incident Heart Failure.JACC. Advances · 2025Article
- Physical Activity and All-Cause Mortality by Age in 4 Multinational Megacohorts.JAMA network open · 2024Article
- Epidemiology and Burden of Heart Failure in Asia.JACC. Asia · 2024Review
- Association of Sleep Pattern and Genetic Susceptibility with Obstructive Sleep Apnea: A Prospective Analysis of the UK Biobank.Nature and science of sleep · 2024Article
- Time spent in a better cardiovascular health and risk of cardiovascular diseases and mortality: a prospective cohort study.Journal of translational medicine · 2023Article
- Cardiovascular health metrics and risk of heart failure in a Finnish population: a prospective cohort study.ESC heart failure · 2023Article
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Authors and funding
18 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundBoth genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea cardiovascular health metrics (ICVHMs) offset the genetic association with incident HF remains unclear.
objectivesTo investigate the genetic association with incident HF as well as the modification effect of ICVHMs on such genetic association in Chinese and British populations.
methodsAn ICVHMs based on smoking, drinking, physical activity, diets, body mass index, waist circumference, blood pressure, blood glucose, and blood lipids, and a polygenic risk score (PRS) for HF were constructed in the China Kadoorie Biobank (CKB) of 96,014 participants and UK Biobank (UKB) of 335,782 participants which were free from HF and severe chronic diseases at baseline.
resultsDuring the median follow-up of 11.38 and 8.73 years, 1451 and 3169 incident HF events were documented in CKB and UKB, respectively. HF risk increased monotonically with the increase of PRS per standard deviation (CKB: hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.07, 1.32; UKB: 1.07; 1.03, 1.11; P for trend < 0.001). Each point increase in ICVHMs was associated with 15% and 20% lower risk of incident HF in CKB (0.85; 0.81, 0.90) and UKB (0.80; 0.77, 0.82), respectively. Compared with unfavorable ICVHMs, favorable ICVHMs was associated with a lower HF risk, with 0.71 (0.44, 1.15), 0.41 (0.22, 0.77), and 0.48 (0.30, 0.77) in the low, intermediate, and high genetic risk in CKB and 0.34 (0.26, 0.44), 0.32 (0.25, 0.41), and 0.37 (0.28, 0.47) in UKB (P for multiplicative interaction > 0.05). Participants with low genetic risk and favorable ICVHMs, as compared with high genetic risk and unfavorable ICVHMs, had 56~72% lower risk of HF (CKB 0.44; 0.28, 0.70; UKB 0.28; 0.22, 0.37). No additive interaction between PRS and ICVHMs was observed (relative excess risk due to interaction was 0.05 [-0.22, 0.33] in CKB and 0.04 [-0.14, 0.22] in UKB).
conclusionsIn CKB and UKB, genetic risk and ICVHMs were independently associated with the risk of incident HF, which suggested that adherence to favorable cardiovascular health status was associated with a lower HF risk among participants with all gradients of genetic risk.
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