ArticleBMC public health2021
Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China.
Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.Current neurovascular research · 2026Pooled it
- Immersive Virtual Reality for Stroke Rehabilitation: Linking Clinical and Digital Measures of Motor Recovery-A Pilot Study.Bioengineering (Basel, Switzerland) · 2026Article
- Trend analysis of stroke subtypes mortality attributable to high body-mass index in China from 1990 to 2019.BMC public health · 2024Article
- The Tryptophan Index Is Associated with Risk of Ischemic Stroke: A Community-Based Nested Case-Control Study.Nutrients · 2024Article
- Management of ischaemic stroke survivors in primary care setting: the road to holistic care.Internal and emergency medicine · 2024Review
- Article
- Associations between diagnosis with stroke, comorbidities, and activity of daily living among older adults in the United States.Chronic diseases and translational medicine · 2023Article
- Assessment of Knowledge and attitude towards Stroke among the UAE population during the COVID-19 pandemic: A cross-sectional study.F1000Research · 2023Article
- Is the National Institute of Health Stroke Scale a valid prognosticator of the aftermath in patients with ischemic stroke?Journal of family medicine and primary care · 2022Article
- Exploring Gender-Specific Stroke Risks in Diabetic Patients: Insights from a Retrospective Analysis of Contributing Factors.Iranian journal of nursing and midwifery researchArticle
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6 authors.
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Abstract
backgroundComorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of a stroke. However, the association of pre-existing comorbidities with stroke risk has not been fully studied.
methodsThis study included 16,246 adults from a prospective community-based cohort with a baseline survey conducted in 2013 in China. Participants were followed up with hospitalization records and the Cause of Death Registry. The association of eight pre-existing comorbidities (coronary heart disease, hyperlipidemia, hypertension, diabetes, previous stroke, chronic obstructive pulmonary disease, nephropathy, and cancer) with stroke risk was analyzed using the Cox proportional hazard model in 2020.
resultsAt a median follow-up of 5.5 years, a total of 449 participants (206 men and 243 women) developed a stroke. Four pre-existing comorbidities (hypertension, congenital heart disease, previous stroke, and diabetes) were independently and positively associated with the risk for all types of stroke. The adjusted hazard ratios for participants with only 1 and ≥ 2 pre-existing comorbidities compared with those without pre-existing conditions were 1.96 (95% CI: 1.44, 2.67; P < 0.001) and 2.87 (95% CI; 2.09, 3.94; P < 0.001) for total stroke, respectively. Moreover, male and female participants with a combination of increased age and a higher number of pre-existing comorbidities experienced the greatest risk of stroke.
conclusionsThe number of pre-existing comorbidities was independently associated with an increased risk of stroke. There was a synergic effect between increased age and a higher number of pre-existing comorbidities on stroke occurrence. Our novel findings emphasize the importance and potential application of pre-existing comorbidities as a risk indicator in stroke prevention.
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