Evidence map›Paper›PMID 34674492›Full record

ArticleEuropean geriatric medicine2018

Potentially inappropriate medication in palliative care patients according to STOPP-Frail criteria.

Daniel Sevilla-Sánchez, Núria Molist-Brunet, Joan Espaulella-Panicot, Javier González-Bueno, Núria Solà-Bonada, Jordi Amblàs-Novellas, Carles Codina-Jané

Abstract read
PubMed Publisher
In one paragraph

Article in European geriatric medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel Sevilla-SánchezPharmacy Department, Hospital Universitari de Vic - Consorci Hospitalari de Vic, C/Francesc Pla El Vigatà núm 1, 08500, Vic, Barcelona, Spain. danielsevillasanchez@gmail.com.ORCID http://orcid.org/0000-0003-2993-6200
Núria Molist-BrunetAcut Geriatric Unit, Hospital de la Santa Creu de Vic, Vic, Barcelona, Spain.
Joan Espaulella-PanicotGeriatric and Palliative Care Territorial Unit, Hospital de la Santa Creu de Vic, Consorci Hospitalari de Vic, Vic, Barcelona, Spain.
Javier González-BuenoPharmacy Department, Hospital Universitari de Vic - Consorci Hospitalari de Vic, C/Francesc Pla El Vigatà núm 1, 08500, Vic, Barcelona, Spain.
Núria Solà-BonadaPharmacy Department, Hospital Universitari de Vic - Consorci Hospitalari de Vic, C/Francesc Pla El Vigatà núm 1, 08500, Vic, Barcelona, Spain.
Jordi Amblàs-NovellasAcut Geriatric Unit, Hospital de la Santa Creu de Vic, Vic, Barcelona, Spain.
Carles Codina-JanéPharmacy Department, Hospital Universitari de Vic - Consorci Hospitalari de Vic, C/Francesc Pla El Vigatà núm 1, 08500, Vic, Barcelona, Spain.

Funding

Consultori Bayes Bayes award to PhD Research 2015
6 · The paper itself

Abstract

backgroundPotentially inappropriate medications (PIMs) are common in palliative care patients, but no specific tools have been used to determine these PIMs.

objectiveTo evaluate the prevalence of PIMs according to specific tool 'STOPP-Frail', related factors with its existence and clinical consequences.

methodsThis is a post hoc analysis from a 10-month prospective cross-sectional study. Upon hospital admission in an acute geriatric unit (AGU), demographic and pharmacological data were collected to determine related associated factors. The main outcome was prevalence and type of PIMs (by STOPP-Frail criteria). Measured clinical outcomes were adverse drug events, length of stay, location upon discharge, in-hospital mortality and 1-year survival.

resultsTwo hundred thirty-five patients (mean age 86.80; 65.50% women) were recruited. Overall, 67.2% of patients had ≥ 1 criterion (mainly 'drugs without clinical indication' due to alimentary tract and metabolism drugs). Related factors associated with PIMs according to STOPP-Frail criteria were moderate polypharmacy (OR 7.16 CI 95% 2.27-22.52) and excessive polypharmacy (OR 7.30 CI 95% 2.34-22.73), but not advanced age (OR 0.26 CI 95% 0.12-0.53) or previous hospitalisations (OR 0.61 CI 95% 0.48-0.79). There were no differences in clinical outcomes.

conclusionPIMs according to STOPP-Frail are often used in palliative care patients. PIMs were associated with polypharmacy, but no related morbidity or mortality effects have been observed.

Indexed as

Chronic diseasePalliative carePotentially inappropriate medicationsSTOPP-Frail criteria

Identifiers

PMID34674492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.