ArticlePediatric obesity2022
Foetal tobacco and cannabis exposure, body fat and cardio-metabolic health in childhood.
Article in Pediatric obesity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The Relationship Between Paternal Smoking and Overweight/Obesity with Childhood Overweight/Obesity: A Systematic Review.Current obesity reports · 2025Pooled it
- Maternal smoking in pregnancy and blood pressure during childhood and adolescence: a meta-analysis.European journal of pediatrics · 2023Pooled it
- The changing landscape of cannabis use: impact on maternal health and neonatal outcomes.Pediatric research · 2026Review
- Household Tobacco Expenditure and Child Health Outcomes: Causal Evidence from a Transitional Economy.Healthcare (Basel, Switzerland) · 2025Article
- Carotid intima-media thickness and endothelial function in adolescents exposed to alcohol consumption and cigarette smoking in utero: a mediation analysis.BMC cardiovascular disorders · 2025Article
- Maternal Smoking Intensity During Pregnancy and Early Adolescent Cardiovascular Health.Journal of the American Heart Association · 2025Article
- Impact of prenatal exposure to delta 9-tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories.Pediatric obesity · 2025Article
- Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.Developmental psychology · 2024Review
- Effects of prenatal THC vapor exposure on body weight, glucose metabolism, and feeding behaviors in chow and high-fat diet fed rats.International journal of obesity (2005) · 2024Article
- Prenatal Exposure to Cannabis: Effects on Childhood Obesity and Cardiometabolic Health.Current obesity reports · 2024Review
- Vascular Effects, Potential Pathways and Mediators of Fetal Exposure to Alcohol and Cigarette Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2023Review
- Prenatal tobacco and cannabis co-exposure and offspring obesity development from birth to mid-childhood.Pediatric obesity · 2023Article
- Pre- and postnatal exposure to secondhand tobacco smoke and cardiometabolic risk at 12 years: Periods of susceptibility.Environmental research · 2023Article
- Tobacco and Cannabis Use During and After Pregnancy in California.Maternal and child health journal · 2023Article
- Fetal Exposure to Maternal Smoking and Neonatal Metabolite Profiles.Metabolites · 2022Article
- Fetal Exposure to Cannabis and Childhood Metabolic Outcomes: The Healthy Start Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Foetal tobacco and cannabis exposure, body fat and cardio-metabolic health in childhood.Pediatric obesity · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFoetal tobacco and cannabis exposure may have persistent cardio-metabolic consequences in the offspring.
objectiveWe examined the associations of maternal and paternal tobacco and cannabis use during pregnancy with offspring body fat and cardio-metabolic outcomes.
methodsIn a population-based prospective cohort study among 4792 mothers, fathers, and children, we assessed parental substance use by questionnaires. Childhood outcomes included body mass index (BMI), body fat, blood pressure, and lipid, glucose and insulin concentrations at 10 years.
resultsChildren exposed to maternal tobacco use during pregnancy had a higher android/gynoid fat mass ratio (difference 0.22 SDS, 95% confidence interval [CI]: 0.13, 0.30), fat mass index (difference 0.20 SDS, 95% CI: 0.12, 0.28), triglyceride concentrations (difference 0.15 SDS, 95% CI: 0.04, 0.26), and a higher risk of overweight (odds ratio [OR] 1.35, 95% CI: 1.07, 1.71), compared to non-exposed. Children exposed to maternal cannabis during pregnancy had a higher BMI (difference 0.26 SDS, 95% CI: 0.08, 0.44), android/gynoid fat mass ratio (difference 0.21 SDS, 95% CI: 0.04, 0.39), and fat-free mass index (difference 0.24 SDS, 95% CI: 0.06, 0.41), compared to non-exposed. The associations for paternal substance use with child cardio-metabolic health outcomes were similar as those for maternal use.
conclusionsSimilar associations for maternal and paternal substance use during pregnancy suggest that these findings may be explained by shared family-based social and lifestyle factors, rather than by direct foetal programming.
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Registered trials
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