Evidence map›Paper›PMID 34674319›Full record

ArticleMycoses2022

COVID-19-associated mucormycosis, diabetes and steroid therapy: Experience in a single centre in Western Mexico.

Salvador Guzmán-Castro, Luis David Chora-Hernandez, Gersain Trujillo-Alonso, Ivan Calvo-Villalobos, Antonio Sanchez-Rangel, Edgar Ferrer-Alpuin, Miguel Ruiz-Jimenez, Dora E Corzo-Leon

Abstract read
In one paragraph

Article in Mycoses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salvador Guzmán-CastroHospital General "Dr. Miguel Silva" SSM, Morelia, Mexico.
Luis David Chora-HernandezHospital General "Dr. Miguel Silva" SSM, Morelia, Mexico.
Gersain Trujillo-AlonsoHospital General "Dr. Miguel Silva" SSM, Morelia, Mexico.
Ivan Calvo-VillalobosHospital General "Dr. Miguel Silva" SSM, Morelia, Mexico.
Antonio Sanchez-RangelHospital General "Dr. Miguel Silva" SSM, Morelia, Mexico.
Edgar Ferrer-AlpuinHospital General "Dr. Miguel Silva" SSM, Morelia, Mexico.
Miguel Ruiz-JimenezMicrobiology Gerency, Asesores Diagnóstico Clínico, Puebla, Mexico.
Dora E Corzo-LeonThe Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.ORCID https://orcid.org/0000-0003-4012-1045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19-associated mucormycosis (CAM) has emerged as a challenging complication as the current pandemic has increased the population requiring treatment with corticosteroids. CAM has caused a massive outbreak in India, reported to be causing cases in Iran, Egypt and The Netherlands.

objectivesTo describe CAM cases occurring in a single centre in Western Mexico.

methodsOur group carried out a retrospective study from May 2020 to May 2021 to identify CAM cases in patients with previous COVID-19 diagnosis.

resultsSix CAM cases occurred in a single centre in Western Mexico during the study period, most of them with diabetes (n = 5/6) and all received corticosteroid therapy even when only three had severe COVID-19. After analysing local COVID-19 burden, it was estimated that in this region, CAM was 300 times more frequent among COVID individuals than the estimates for general population.

conclusionSimilar to large reports in India and other countries, CAM cases reported in this study were diagnosed in individuals with diabetes, hyperglycaemic status and with history of previous use of corticosteroids. Identifying these individuals at risk can help the early identification of CAM. In addition, strict glycaemic control and avoidance of unnecessary corticosteroid in non-severe COVID-19 cases could help in preventing this complicated fungal infection.

Indexed as

COVID-19COVID-19 Drug TreatmentDiabetes MellitusMucormycosisAdrenal Cortex HormonesAntifungal AgentsCOVID-19 TestingHumansMexicoRetrospective StudiesSteroidsAdrenal Cortex HormonesAntifungal AgentsSteroidsCAMcorticosteroidsCOVID-19diabetesinfectionmucormycosisROCMSARS-CoV-2

Identifiers

PMID34674319
PMCPMC8662123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.