ReviewJournal of neurology2022
Acute and post-acute neurological manifestations of COVID-19: present findings, critical appraisal, and future directions.
Review in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 88 citations in OpenAlex.
- Review
- Prevalence and Persistence of Post-COVID-19 Condition After Critical Care: 32-Month Follow-Up.Journal of clinical medicine · 2026Article
- The Timing of Intrauterine Exposure to Maternal SARS-CoV-2 Infection Impacts Neurodevelopment and Growth Trajectories During the First Year of Life.Journal of clinical medicine · 2026Article
- Review
- The Neuroinfectious diseases profile in a specialist neurology centre in South Africa.eNeurologicalSci · 2025Article
- Brain organoids: building higher-order complexity and neural circuitry models.Trends in biotechnology · 2025Review
- Increasing incidence of ADHD among children, adolescents and young adults: COVID-19 pandemic-driven trend in Korea (2012-2023).BMJ mental health · 2025Observational
- Neuroinflammation in Severe COVID-19: The Dynamics of Inflammatory and Brain Injury Markers During Hospitalization.Molecular neurobiology · 2025Article
- Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review.eNeurologicalSci · 2025Review
- Diagnostic Models for Differentiating COVID-19-Related Acute Ischemic Stroke Using Machine Learning Methods.Diagnostics (Basel, Switzerland) · 2024Article
- Impact of SARS-CoV-2 Infection on Essential Tremor: A Retrospective Clinical and Kinematic Analysis.Cerebellum (London, England) · 2024Article
- Headache severity in patients with post COVID-19 condition: a case-control study.European archives of psychiatry and clinical neuroscience · 2024Article
- Sex Differences in Long-Term Cardiovascular Outcomes and Mortality After COVID-19 Hospitalization During Alpha, Delta and Omicron Waves.Journal of clinical medicine · 2024Article
- Acute and Preventive Treatment of COVID-19-Related Headache: A Series of 100 Patients.Life (Basel, Switzerland) · 2024Article
- Relative frequencies and clinical features of Guillain-Barré Syndrome before and during the COVID-19 pandemic in North China.BMC infectious diseases · 2024Article
- LIMBIC-CENC: Successfully conducting longitudinal mTBI research during the COVID-19 pandemic.NeuroRehabilitation · 2024Article
- Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease.Frontiers in immunology · 2024Review
- Evolving Clinical Manifestations and Outcomes in COVID-19 Patients: A Comparative Analysis of SARS-CoV-2 Variant Waves in a Romanian Hospital Setting.Pathogens (Basel, Switzerland) · 2023Article
- Pitfalls and biases in neuroepidemiological studies of COVID-19 and the nervous system: a critical appraisal of the current evidence and future directions.Journal of neurology · 2023Review
- SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier.Fluids and barriers of the CNS · 2023Article
Corrections and comments
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Authors and funding
13 authors at 11 institutions in 11 countries.
Funding
Abstract
Acute and post-acute neurological symptoms, signs and diagnoses have been documented in an increasing number of patients infected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which causes Coronavirus Disease 2019 (COVID-19). In this review, we aimed to summarize the current literature addressing neurological events following SARS-CoV-2 infection, discuss limitations in the existing literature and suggest future directions that would strengthen our understanding of the neurological sequelae of COVID-19. The presence of neurological manifestations (symptoms, signs or diagnoses) both at the onset or during SARS-CoV-2 infection is associated with a more severe disease, as demonstrated by a longer hospital stay, higher in-hospital death rate or the continued presence of sequelae at discharge. Although biological mechanisms have been postulated for these findings, evidence-based data are still lacking to clearly define the incidence, range of characteristics and outcomes of these manifestations, particularly in non-hospitalized patients. In addition, data from low- and middle-income countries are scarce, leading to uncertainties in the measure of neurological findings of COVID-19, with reference to geography, ethnicity, socio-cultural settings, and health care arrangements. As a consequence, at present a specific phenotype that would specify a post-COVID (or long-COVID) neurological syndrome has not yet been identified.
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Registered trials
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