Evidence map›Paper›PMID 34673980›Full record

ArticleMetallomics : integrated biometal science2021

Vanadate inhibits Feo-mediated iron transport in Vibrio cholerae.

Minhye Shin, Camilo Gomez-Garzon, Shelley M Payne

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metallomics : integrated biometal science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Minhye ShinDepartment of Microbiology, College of Medicine, Inha University, Incheon 22212, Republic of Korea.
Camilo Gomez-GarzonDepartment of Molecular Biosciences, LaMontagne Center for Infectious Disease, The University of Texas at Austin, Austin, TX 78712, USA.
Shelley M PayneDepartment of Molecular Biosciences, LaMontagne Center for Infectious Disease, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0003-3112-4340
The University of Texas at Austin · USInha University · KR

Funding

Characterization of the ferrous iron transporter Feo in Vibrio choleraeR01AI091957 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI PAYNE, SHELLEY M. · 2011 to 2021
$3.9M
NIAID NIH HHS R01 AI091957
6 · The paper itself

Abstract

Iron is an essential element for Vibrio cholerae to survive, and Feo, the major bacterial system for ferrous iron transport, is important for growth of this pathogen in low-oxygen environments. To gain insight into its biochemical mechanism, we evaluated the effects of widely used ATPase inhibitors on the ATP hydrolysis activity of the N-terminal domain of V. cholerae FeoB. Our results showed that sodium orthovanadate and sodium azide effectively inhibit the catalytic activity of the N-terminal domain of V. cholerae FeoB. Further, sodium orthovanadate was the more effective inhibitor against V. cholerae ferrous iron transport in vivo. These results contribute to a more comprehensive biochemical understanding of Feo function, and shed light on designing effective inhibitors against bacterial FeoB proteins.

Indexed as

Adenosine TriphosphateAzidesBiological TransportCatalysisHydrolysisIronMolecular Docking SimulationVanadatesVibrio choleraeAdenosine TriphosphateAzidesIronVanadates

Identifiers

PMID34673980
PMCPMC8715895
OpenAlexW3206925140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.