ArticleThe Journal of antimicrobial chemotherapy2021
Large diversity of linezolid-resistant isolates discovered in food-producing animals through linezolid selective monitoring in Belgium in 2019.
Article in The Journal of antimicrobial chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Occurrence of Antimicrobial Resistance in Indicator Bacteria andAntibiotics (Basel, Switzerland) · 2026Article
- Genomic analysis of Enterococcus faecium co-carrying optrA and poxtA from a swine farm: dissemination across the human-animal-environment interface.BMC microbiology · 2026Article
- Global distribution and genomic characteristics of linezolid resistance gene-positiveFrontiers in microbiology · 2026Article
- Antimicrobial Resistance Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Resistance to last-resort antibiotics in enterococci.FEMS microbiology reviews · 2025Review
- Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novelFrontiers in microbiology · 2025Article
- Risk Factor Analysis for Occurrence of Linezolid-Resistant Bacteria in the Digestive and Respiratory Tract of Food-Producing Animals in Belgium: A Pilot Study.Antibiotics (Basel, Switzerland) · 2024Article
- Communicating and disseminating One Health: successes of the One Health European Joint Programme.Journal of medical microbiology · 2024Article
- Mapping the widespread distribution and transmission dynamics of linezolid resistance in humans, animals, and the environment.Microbiome · 2024Article
- Genomic characteristics of cfr and fexA carrying Staphylococcus aureus isolated from pig carcasses in Korea.Veterinary research · 2024Article
- Prevalence ofPathogens (Basel, Switzerland) · 2023Article
- Nasal staphylococci community of healthy pigs and pig-farmers in Aragon (Spain). Predominance and within-host resistome diversity in MRSA-CC398 and MSSA-CC9 lineages.One health (Amsterdam, Netherlands) · 2023Article
- Nasotracheal enterococcal carriage and resistomes: detection of optrA-, poxtA- and cfrD-carrying strains in migratory birds, livestock, pets, and in-contact humans in Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Antibiotic Resistance Profiles and ARG Detection from Isolated Bacteria in a Culture-Dependent Study at the Codfish Industry Level.Foods (Basel, Switzerland) · 2023Article
- Determination of Epidemiological Cutoff Values for Antimicrobial Resistance of Enterococcus cecorum.Journal of clinical microbiology · 2023Article
- Occurrence ofAntibiotics (Basel, Switzerland) · 2023Article
- High occurrence ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.MicrobiologyOpen · 2023Article
- Oxazolidinone resistance genes in florfenicol-resistant enterococci from beef cattle and veal calves at slaughter.Frontiers in microbiology · 2023Article
- Plasmid-Coded Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus from Food and Livestock in GermanyAntibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLinezolid is a critically important antibiotic used to treat human infections caused by MRSA and VRE. While linezolid is not licensed for food-producing animals, linezolid-resistant (LR) isolates have been reported in European countries, including Belgium.
objectivesTo: (i) assess LR occurrence in staphylococci and enterococci isolated from different Belgian food-producing animals in 2019 through selective monitoring; and (ii) investigate the genomes and relatedness of these isolates.
methodsFaecal samples (n = 1325) and nasal swab samples (n = 148) were analysed with a protocol designed to select LR bacteria, including a 44-48 h incubation period. The presence of LR chromosomal mutations, transferable LR genes and their genetic organizations and other resistance genes, as well as LR isolate relatedness (from this study and the NCBI database) were assessed through WGS.
resultsThe LR rate differed widely between animal host species, with the highest rates occurring in nasal samples from pigs and sows (25.7% and 20.5%, respectively) and faecal samples from veal calves (16.4%). WGS results showed that LR determinants are present in a large diversity of isolates circulating in the agricultural sector, with some isolates closely related to human isolates, posing a human health risk.
conclusionsLR dedicated monitoring with WGS analysis could help to better understand the spread of LR. Cross-selection of LR transferable genes through other antibiotic use should be considered in future action plans aimed at combatting antimicrobial resistance and in future objectives for the rational use of antibiotics in a One Health perspective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.