ArticleBlood purification2022
Development and External Validation of a Model for Predicting Sufficient Filter Lifespan in Anticoagulation-Free Continuous Renal Replacement Therapy Patients.
Article in Blood purification, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis.Renal failure · 2024Pooled it
- Higher blood flow rates in anticoagulation-free CRRT improve circuit survival and clinical outcome.Clinical kidney journal · 2026Article
- Machine learning model predicts clotting risk during CRRT in ESKD patients: a SHAP-interpretable approach.Renal failure · 2025Article
- [Factors affecting filter lifespan in patients receiving continuous renal replacement therapy at a tertiary hospital in South Korea: a cross-sectional descriptive study].Journal of Korean biological nursing science · 2025Article
- Serum ionised calcium, thrombin time (TT), fibrinogen (FIB) after heparin and sodium citrate anticoagulation in children with sepsis.Journal of medical biochemistry · 2025Article
- Article
- Incorporation of oXiris Bioabsorbent Filter into CRRT in the treatment of severe abdominal infections and analysis of associated risk factors for early off-machine.Frontiers in public health · 2025Article
- Coagulation Risk Predicting in Anticoagulant-Free Continuous Renal Replacement Therapy.Blood purification · 2024Article
- Exploring the Potential of Chatbots in Critical Care Nephrology.Medicines (Basel, Switzerland) · 2023Review
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12 authors.
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Abstract
backgroundAnticoagulation-free continuous renal replacement therapy (CRRT) was recommended by the current clinical guideline for patients with increased bleeding risk and contraindications of citrate. Nevertheless, anticoagulation-free CRRT yielded heterogeneous filter lifespan. Furthermore, the specific cutoff values for traditional coagulation parameters to predict sufficient filter lifespan of anticoagulation-free CRRT have not yet been determined. The purpose of our present study was to develop and validate a model for predicting sufficient filter lifespan in anticoagulation-free CRRT patients.
methodsPatients who underwent anticoagulation-free CRRT in our center between June 2013 and June 2019 were retrospectively included. The primary outcome was sufficient filter lifespan (≥24 h). Thirty-seven predictors were included for modeling based on their clinical significance and previous reports. The final model was developed by using multivariable logistic regression analysis and was validated in a separate external cohort.
resultsThe development cohort included 170 patients. Sufficient filter lifespan was observed in 80 patients. Thirteen variables were independent predictors for sufficient filter lifespan by logistic regression: body temperature, mean arterial pressure, activated partial thromboplastin time, direct bilirubin, alkaline phosphatase, blood urea nitrogen, vasopressor use, body mass index, white blood cell, platelet count, D-dimer, uric acid, and pH. The area under the curve (AUC) of the stepwise model and internal validation model was 0.82 (95% confidence interval [CI] [0.76-0.88]) and 0.8 (95% CI [0.74-0.87]), respectively. The positive predictive value and the negative predictive value of the stepwise model were 0.77 and 0.79, respectively. The validation cohort included 44 eligible patients and the AUC of the external validation model was 0.82 (95% CI [0.69-0.96]).
conclusionsThe use of a prediction model instead of an assessment based only on coagulation parameters could facilitate the identification of the patients with filter lifespan of ≥24 h when they accepted anticoagulation-free CRRT.
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