Evidence map›Paper›PMID 34673386›Full record

ArticleSchizophrenia research2021

Association between residential instability at individual and area levels and future psychosis in adolescents at clinical high risk from the North American Prodrome Longitudinal Study (NAPLS) consortium.

Benson S Ku, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Michael T Compton, Barbara A Cornblatt, Matcheri Keshavan, Daniel H Mathalon, Diana O Perkins and 5 more

Abstract read
In one paragraph

Article in Schizophrenia research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Benson S KuDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States. Electronic address: bsku@emory.edu.
Jean AddingtonDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los Angeles, United States.
Kristin S CadenheadDepartment of Psychiatry, University of California, San Diego, CA, United States.
Tyrone D CannonDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Michael T ComptonDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY, United States.
Barbara A CornblattDepartment of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United States.
Matcheri KeshavanHarvard Medical School, Departments of Psychiatry at Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, MA, United States.
Daniel H MathalonDepartment of Psychiatry, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, United States.
William S StoneHarvard Medical School, Departments of Psychiatry at Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, MA, United States.
Ming T TsuangDepartment of Psychiatry, University of California, San Diego, CA, United States.
Elaine F WalkerDepartment of Psychology, Emory University, Atlanta, GA, United States.
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Benjamin G DrussDepartment of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, GA, United States.

Funding

STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YEE-BRADBURY, CINDY M. · 2003 to 2014
$18.6M
1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
Functional Brain Abnormalities in the Schizophrenia ProdromeR01MH076989 · NIMH · YALE UNIVERSITY · PI MATHALON, DANIEL H · 2007 to 2014
$2.3M
Emory Psychiatry Clinical Scientist Training Program (CSTP)R25MH101079 · NIMH · EMORY UNIVERSITY · PI GOLDSMITH, DAVID RYAN, MILLER, ANDREW H · 2014 to 2025
$1.9M
Enhancing the Prospective Prediction of PsychosisU01MH066069 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2003 to 2007
$1.5M
Enhancing the Prospective Prediction of PsychosisU01MH066134 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI ADDINGTON, JEAN M · 2003 to 2007
$869k
NIMH NIH HHS P50 MH066286NIMH NIH HHS R01 MH076989NIMH NIH HHS R25 MH101079NIMH NIH HHS U01 MH066069NIMH NIH HHS U01 MH066134NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH081988NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

objectiveAccumulating evidence supports an association between residential instability and increased risk for psychosis, but the association between residential instability and conversion to psychosis among adolescents at clinical high risk (CHR) is unclear. In this study, we determined whether individual-level and area-level residential instability and their interaction are associated with conversion to psychosis within two years.

methodsData were collected as part of the North American Prodrome Longitudinal Study Phase 2. Individual-level residential instability, defined as having ever moved during lifetime, was derived from the Life Events Scale. Area-level residential instability, defined as the percentage of people who were not living in the same house five years ago, was derived from the U.S. Decennial Censuses.

resultsThis study included 285 adolescents at CHR (including 36 subjects who later converted to full psychosis). We found that individual-level residential instability was associated with conversion (adjusted OR = 2.769; 95% CI = 1.037-7.393). The interaction between individual-level and area-level residential instability was significant (p = 0.030). In a subgroup of CHR participants who have never moved (n = 91), area-level residential instability during childhood was associated with conversion (adjusted OR = 1.231; 95% CI = 1.029-1.473). Conversely, in a subgroup of CHR participants who resided in residentially stable areas during childhood (n = 142), the association between individual-level residential instability and conversion remained significant (adjusted OR = 15.171; 95% CI = 1.753-131.305).

conclusionsThese findings suggest that individual-level and area-level residential instability may be associated with conversion to psychosis.

Indexed as

Prodromal SymptomsPsychotic DisordersAdolescentHumansLongitudinal StudiesNorth AmericaClinical high risk for psychosisProdromeResidential instability

Identifiers

PMID34673386
PMCPMC10800030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.