Observational studyOphthalmology. Glaucoma
Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.
Observational study in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ocular Blood Flow Imaging for Glaucoma Assessment
Evaluation of Patients With Retinal Disorders Utilizing the XyCAM CRE Camera.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Intraday and Interday Repeatability of Laser Speckle Contrast Imaging for Ocular Blood Flow Measurement in Healthy Subjects.Translational vision science & technology · 2026Article
- Article
- Comparing infant pain and stress during retinopathy of prematurity screening using ophthalmoscopy and non-contact imaging.Scientific reports · 2025Article
- A clinical research: blood perfusion of artificial dermis detected by laser speckle contrast imaging influence the therapeutic effect on wound healing.Lasers in medical science · 2025Article
- Laser speckle contrast imaging detects relative blood flow reduction in traumatic optic neuropathy.American journal of ophthalmology case reports · 2025Article
- Effects and Safety of Press-Needle Therapy for Improving Visual Function and Eye Blood Circulation in Patients With Glaucoma With Controlled Intraocular Pressure: Study Protocol for a Multicenter Randomized Controlled Trial.JMIR research protocols · 2025Article
- Comprehensive validation of a compact laser speckle contrast imaging system for vascular function assessment: from the laboratory to the clinic.Medical & biological engineering & computing · 2025Article
- Real-time monitoring of spinal cord hemodynamics with laser speckle contrast imaging during pedicle subtraction osteotomy in rabbits.Frontiers in surgery · 2025Article
- Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.Biomedical optics express · 2024Article
- Retinal blood flow association with age and weight in infants at risk for retinopathy of prematurity.Scientific reports · 2024Article
- Super-Resolution Ultrasound Localization Microscopy Using High-Frequency Ultrasound to Measure Ocular Perfusion Velocity in the Rat Eye.Bioengineering (Basel, Switzerland) · 2023Article
- Current State of Knowledge in Ocular Blood Flow in Glaucoma: A Narrative Review.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Inter-day repeatability assessment of human retinal blood flow using clinical laser speckle contrast imaging.Biomedical optics express · 2022Article
- Retinal Blood Flow Decreases after Treatment with Bevacizumab for Retinopathy of Prematurity.Ophthalmology scienceArticle
- Association of Speckle-Based Blood Flow Measurements and Fluorescein Angiography in Infants with Retinopathy of Prematurity.Ophthalmology scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo assess the repeatability of blood flow velocity index (BFVi) metrics obtained with a recently Food and Drug Administration-cleared laser speckle contrast imaging device, the XyCAM RI (Vasoptic Medical, Inc), and to characterize differences in these metrics among control, glaucoma suspect, and glaucoma participants.
designProspective, observational study.
participantsForty-six participants: 20 control, 16 glaucoma suspect, and 10 glaucoma participants, 1 eye per participant.
methodsKey dynamic BFVi metrics-mean, peak, dip, volumetric rise index (VRI), volumetric fall index (VFI), time to rise (TtR), time to fall (TtF), blow-out time (BOT), skew, and acceleration time index-were measured in the optic disc, optic disc vessels, optic disc perfusion region, and macula in 4 imaging sessions on the same day. Intrasession and intersession variability were calculated using the coefficient of variation (CV) for each metric in each region of interest (ROI). Values for each dynamic BFVi variable were compared between glaucoma, glaucoma suspect, and control participants using bivariate and multivariate analysis. Pearson correlation coefficients were used to correlate each variable in each ROI with age, intraocular pressure, cup-to-disc ratio (CDR), mean deviation, pattern standard deviation, retinal nerve fiber layer thickness, and minimum rim width.
main outcome measuresCoefficient of variation for the intrasession and intersession variability for each dynamic BFVi metric in each ROI and differences in each metric in each ROI between each diagnostic group.
resultsIntersession CV for mean, peak, dip, VRI, VFI, TtR, and TtF ranged from 3.2 ± 2.5% to 11.0 ± 3.8%. Age, CDR, OCT metrics, and visual field metrics showed significant correlations with dynamic BFVi variables. Peak, mean, dip, VRI, and VFI were significantly lower in patients with glaucoma than in control participants in all ROIs except the fovea. These metrics also were significantly lower in glaucoma patients than glaucoma suspect patients in the disc vessels.
conclusionsDynamic blood flow metrics measured with the XyCAM RI are reliable, are associated with structural and functional glaucoma metrics, and are significantly different among glaucoma, glaucoma suspect, and control participants. The XyCAM RI may serve as an important tool in glaucoma management in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.