Evidence map›Paper›PMID 34673177›Full record

ArticleBrain, behavior, and immunity2022

Socioeconomic Status and Inflammation in Women with Early-stage Breast Cancer: Mediation by Body Mass Index.

Yrvane K Pageot, Annette L Stanton, Patricia A Ganz, Michael R Irwin, Steve W Cole, Catherine M Crespi, Elizabeth C Breen, Kate R Kuhlman, Julienne E Bower

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Care Needs and Symptoms Burden of Breast Cancer Patients in Jordan: A Cross-Sectional Study.International journal of environmental research and public health · 2022
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yrvane K PageotDepartment of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA. Electronic address: yp585@ucla.edu.
Annette L StantonDepartment of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA; Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza Driveway, Los Angeles, CA 90095, USA; UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90024, USA.
Patricia A GanzUCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90024, USA; Schools of Medicine and Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Michael R IrwinDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA; Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza Driveway, Los Angeles, CA 90095, USA.
Steve W ColeDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA; Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza Driveway, Los Angeles, CA 90095, USA; Department of Medicine, University of California, Los Angeles, 100 Medical Plaza Driveway, Los Angeles, CA, 90095, USA.
Catherine M CrespiUCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90024, USA; Department of Biostatistics, University of California, Los Angeles, 650 Charles E. Young Dr. South, Los Angeles, CA 90095, USA.
Elizabeth C BreenCousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza Driveway, Los Angeles, CA 90095, USA.
Kate R KuhlmanCousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza Driveway, Los Angeles, CA 90095, USA; Department of Psychological Science, University of California, Irvine, 201 Social & Behavioral Sciences Gateway, Irvine, CA 92697, USA.
Julienne E BowerDepartment of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA; Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza Driveway, Los Angeles, CA 90095, USA; UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90024, USA.
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patientsR01CA160427 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2012 to 2016
$3.2M
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA160427NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

backgroundBreast cancer is the most common cancer among women in the US, and women of low socioeconomic status (SES) show markedly poorer outcomes than those of high SES. SES may influence health through inflammation, although links between SES and inflammatory biomarkers have not been investigated in women with breast cancer. This study tested the hypothesis that breast cancer patients of lower SES would show higher levels of inflammation than those of higher SES. BMI was examined as a mediator of this association.

methodsWomen recently diagnosed with early-stage breast cancer (N = 194) were recruited before neoadjuvant or adjuvant therapy. Participants completed questionnaires and provided blood samples for immune assessment. SES was indexed by participants' self-reported education and annual household income, BMI was determined by height and weight measurements, and blood was assayed for inflammatory biomarkers linked with cancer outcomes: IL-6, CRP, TNF-α, and sTNF-RII. General linear models tested associations between SES and inflammation, and mediation models examined indirect effects through BMI.

resultsConsistent with hypotheses, education status was associated with CRP, (F(2,185) = 4.72, p = 0.001), and sTNF-RII, (F(2,185) = 4.19, p = 0.02), such that lower education was associated with higher levels of both biomarkers. Further, BMI mediated the associations between education and CRP, (95% CIs [-0.62, -0.11; -0.76, -0.21]), sTNF-RII, (95% CIs [-0.09, -0.01; -0.10, -0.02]), and IL-6, (95% CIs [-0.32, -0.05; -0.38, -0.09]). Annual household income was not significantly associated with inflammation (ps > 0.25), and indirect effects on inflammation through BMI were not significant.

conclusionsLower education was associated with higher levels of inflammation in this sample, which may presage poor breast cancer-related and clinical outcomes. SES should inform the development of interventions targeting BMI and inflammation in breast cancer.

Indexed as

Breast NeoplasmsBody Mass IndexC-Reactive ProteinFemaleHumansInflammationSocial ClassSocioeconomic FactorsC-Reactive ProteinBody mass indexBreast cancerInflammationSocioeconomic status

Identifiers

PMID34673177
PMCPMC9802182
OpenAlexW3207507601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.