Evidence map›Paper›PMID 34673152›Full record

ArticleResuscitation2021

Risk factors and outcomes for recurrent paediatric in-hospital cardiac arrest: Retrospective multicenter cohort study.

Maria E Frazier, Stephanie R Brown, Amanda O'Halloran, Tia Raymond, Richard Hanna, Dana E Niles, Monica Kleinman, Robert M Sutton, Joan Roberts, Ken Tegtmeyer and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Resuscitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria E FrazierRiley Hospital for Children, Indianapolis, IN, USA. Electronic address: Maria.Frazier@cchmc.org.
Stephanie R BrownUniversity of Iowa Stead Family Children's Hospital, Iowa City, IA, USA; Lucile Packard Children's Hospital, Palo Alto, CA, USA.
Amanda O'HalloranThe Children's Hospital of Philadelphia, Philadelphia, PA, USA; Children's Hospital of San Antonio, San Antonio, TX, USA.
Tia RaymondDartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Richard HannaThe Children's Hospital of Philadelphia, Philadelphia, PA, USA; Children's Hospital of San Antonio, San Antonio, TX, USA.
Dana E NilesThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Monica KleinmanErasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.
Robert M SuttonThe Children's Hospital of Philadelphia, Philadelphia, PA, USA; Children's Hospital of San Antonio, San Antonio, TX, USA.
Joan RobertsOspedale Pediatrico Bambino Gesù, Rome, Italy; Alberta Children's Hospital, Calgary, AB, Canada.
Ken TegtmeyerRiley Hospital for Children, Indianapolis, IN, USA; Children's Hospital at Westmead, Sydney, NSW, Australia.
Heather A WolfeThe Children's Hospital of Philadelphia, Philadelphia, PA, USA; Children's Hospital of San Antonio, San Antonio, TX, USA.
Vinay NadkarniThe Children's Hospital of Philadelphia, Philadelphia, PA, USA; Children's Hospital of San Antonio, San Antonio, TX, USA.
Maya DewanRiley Hospital for Children, Indianapolis, IN, USA; Children's Hospital at Westmead, Sydney, NSW, Australia; Stollery Children's Hospital, Edmonton, AB, Canada.
PediRES-Q Collaborative Investigators

Funding

AHRQ Mentored Clinical Scientist Research Career Development Award (K08): Maya DewanK08HS026975 · AHRQ · CINCINNATI CHILDRENS HOSP MED CTR · PI DEWAN, MAYA L · 2020 to 2024
$752k
AHRQ HHS K08 HS026975
6 · The paper itself

Abstract

aim of studyRecurrent in-hospital cardiac arrest (IHCA) is associated with morbidity and mortality in adults. We aimed to describe the risk factors and outcomes for paediatric recurrent IHCA.

methodsRetrospective cohort study of patients ≤18 years old with single or recurrent IHCA. Recurrent IHCA was defined as ≥2 IHCA within the same hospitalization. Categorical variables expressed as percentages and compared via Chi square test. Continuous variables expressed as medians with interquartile ranges and compared via rank sum test. Outcomes assessed in a propensity match cohort.

resultsFrom July 1, 2015 to January 26, 2021, 139/894 (15.5%) patients experienced recurrent IHCA. Compared to patients with a single IHCA, recurrent IHCA patients were more likely to be trauma and less likely to be surgical cardiac patients. Median duration of cardiopulmonary resuscitation (CPR) was shorter in the recurrent IHCA (5 vs. 11 min; p < 0.001) with no difference in IHCA location or immediate cause of CPR. Patients with recurrent IHCA had worse survival to intensive care unit (ICU) discharge (31% vs. 52%; p < 0.001), and worse survival to hospital discharge (30% vs. 48%; p < 0.001) in unadjusted analyses and after propensity matching, patients with recurrent IHCA still had worse survival to ICU (34% vs. 67%; p < 0.001) and hospital (31% vs. 64%; p < 0.001) discharge.

conclusionWhen examining those with a single vs. a recurrent IHCA, event and patient factors including more pre-existing conditions and shorter duration of CPR were associated with risk for recurrent IHCA. Recurrent IHCA is associated with worse survival outcomes following propensity matching.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestAdolescentAdultChildCohort StudiesHospitals, PediatricHumansRetrospective StudiesRisk FactorsCardiac arrestCPRPaediatricsRecurrent arrestRisk factors

Identifiers

PMID34673152
PMCPMC12448236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.