Evidence map›Paper›PMID 34673103›Full record

ArticleInternational journal of biological macromolecules2021

Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake.

Veedamali S Subramanian, Trevor Teafatiller, Janielle Vidal, Gihan S Gunaratne, Carlos J Rodriguez-Ortiz, Masashi Kitazawa, Jonathan S Marchant

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological macromolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Calsyntenin-3 suppresses inflammation via inhibition of TLR N-glycosylation and membrane localization.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Veedamali S SubramanianDepartment of Medicine, University of California, Irvine, CA 92697, United States of America. Electronic address: vsubrama@uci.edu.
Trevor TeafatillerDepartment of Medicine, University of California, Irvine, CA 92697, United States of America.
Janielle VidalDepartment of Medicine, University of California, Irvine, CA 92697, United States of America; Department of Environmental and Occupational Health, University of California, Irvine, CA 92697, United States of America.
Gihan S GunaratneDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, United States of America.
Carlos J Rodriguez-OrtizDepartment of Medicine, University of California, Irvine, CA 92697, United States of America; Department of Environmental and Occupational Health, University of California, Irvine, CA 92697, United States of America.
Masashi KitazawaDepartment of Medicine, University of California, Irvine, CA 92697, United States of America; Department of Environmental and Occupational Health, University of California, Irvine, CA 92697, United States of America.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, United States of America.
University of California, Irvine · USMedical College of Wisconsin · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
Physiology/pathophysiology of intestinal vitC uptake: Cell/molecular mechanismsR01DK107474 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SUBRAMANIAN, VEEDAMALI S · 2016 to 2020
$2.1M
NIA NIH HHS P30 AG066519NIA NIH HHS P50 AG016573NIDDK NIH HHS R01 DK107474
6 · The paper itself

Abstract

Ascorbic acid (AA) uptake in neurons occurs via a Na

Indexed as

AnimalsAscorbic AcidCalcium-Binding ProteinsCell LineGene ExpressionHippocampusHumansMembrane ProteinsMiceNeuronsProtein BindingSodium-Coupled Vitamin C TransportersTwo-Hybrid System TechniquesAscorbic AcidCalcium-Binding ProteinsCLSTN3 protein, humanMembrane ProteinsSodium-Coupled Vitamin C TransportersAlzheimer's diseaseCLSTN3InteractorSVCT2TransportVitamin C

Identifiers

PMID34673103
PMCPMC9842108
OpenAlexW3206969524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.