Evidence map›Paper›PMID 34673080›Full record

ArticlePreventive medicine2021

Lifecourse socioeconomic position and diabetes incidence in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, 2003 to 2016.

Kimberly D Martin, Gloria L Beckles, Chengyi Wu, Leslie A McClure, April P Carson, Aleena Bennett, Kai McKeever Bullard, M Maria Glymour, Fred Unverzagt, Solveig Cunningham and 2 more

Open access · greenAbstract read
In one paragraph

Article in Preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Kimberly D MartinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: martinkd@uab.edu.
Gloria L BecklesDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotions, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Chengyi WuDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
Leslie A McClureDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
April P CarsonDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Aleena BennettDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Kai McKeever BullardDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotions, Centers for Disease Control and Prevention, Atlanta, GA, USA.
M Maria GlymourDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Fred UnverzagtDepartment of Psychiatry, Indiana School of Medicine, Indianapolis, IN, USA.
Solveig CunninghamDepartment of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Giuseppina ImperatoreDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotions, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Virginia J HowardDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USDrexel University · USNational Center for Chronic Disease Prevention and Health Promotion · USCenters for Disease Control and Prevention · USEmory University · USIndiana University – Purdue University Indianapolis · USUniversity of California, San Francisco · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Childhood SES Factors: Impact on age-related cognitive and vascular healthR01AG039588 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HOWARD, VIRGINIA J. · 2011 to 2016
$2.8M
NIA NIH HHS R01 AG039588NIDDK NIH HHS P30 DK111024NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Low socioeconomic position (SEP) across the lifecourse is associated with Type 2 diabetes (T2DM). We examined whether these economic disparities differ by race and sex. We included 5448 African American (AA) and white participants aged ≥45 years from the national (United States) REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort without T2DM at baseline (2003-07). Incident T2DM was defined by fasting glucose ≥126 mg/dL, random glucose ≥200 mg/dL, or using T2DM medications at follow-up (2013-16). Derived SEP scores in childhood (CSEP) and adulthood (ASEP) were used to calculate a cumulative (CumSEP) score. Social mobility was defined as change in SEP. We fitted race-stratified logistic regression models to estimate the association between each lifecourse SEP indicator and T2DM, adjusting for covariates; additionally, we tested SEP-sex interactions. Over a median of 9.0 (range 7-14) years of follow-up, T2DM incidence was 167.1 per 1000 persons among AA and 89.9 per 1000 persons among white participants. Low CSEP was associated with T2DM incidence among AA (OR = 1.61; 95%CI 1.05-2.46) but not white (1.06; 0.74-2.33) participants; this was attenuated after adjustment for ASEP. In contrast, low CumSEP was associated with T2DM incidence for both racial groups. T2DM risk was similar for stable low SEP and increased for downward mobility when compared with stable high SEP in both groups, whereas upward mobility increased T2DM risk among AAs only. No differences by sex were observed. Among AAs, low CSEP was not independently associated with T2DM, but CSEP may shape later-life experiences and health risks.

Indexed as

Diabetes Mellitus, Type 2StrokeAdultHumansIncidenceMiddle AgedRace FactorsRisk FactorsSocioeconomic FactorsUnited StatesAfrican AmericanLifecourse socioeconomic positionSocial mobilityType 2 diabetes mellitus

Identifiers

PMID34673080
PMCPMC8658048
OpenAlexW3205400930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.