Evidence map›Paper›PMID 34673053›Full record

ArticleBiophysical journal2021

Single-molecule studies reveal regulatory interactions between master kinases PDK1, AKT1, and PKC.

Moshe T Gordon, Brian P Ziemba, Joseph J Falke

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3KγbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Moshe T GordonMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, Colorado.
Brian P ZiembaMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, Colorado.
Joseph J FalkeMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, Colorado. Electronic address: falke@colorado.edu.
University of Colorado Boulder · US

Funding

Mechanisms of Signaling on Membrane SurfacesR01GM063235 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2001 to 2021
$6.4M
Predoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3M
NIGMS NIH HHS R01 GM063235NIGMS NIH HHS T32 GM065103
6 · The paper itself

Abstract

Leukocyte migration is controlled by a leading-edge chemosensory pathway that generates the regulatory lipid phosphatidylinositol-3,4,5-trisphosphate (PIP

Indexed as

Protein Serine-Threonine KinasesSignal TransductionCell MembranePhosphorylationProtein Serine-Threonine Kinases

Identifiers

PMID34673053
PMCPMC8715220
OpenAlexW3205037912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.