Evidence map›Paper›PMID 34672981›Full record

ArticleNeuron2021

MiR-218 steps down to a threshold of motor impairment.

Victoria A Church, Andrew S Yoo

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Victoria A ChurchDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew S YooDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yooa@wustl.edu.

Funding

Modeling Neuronal Aging and Alzheimer's Disease in Human Neurons Directly Converted from FibroblastsRF1AG056296 · NIA · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2017 to 2017
$1.9M
Mechanistic insights into neurodegeneration in Huntington's disease using patient-derived neurons through direct conversion of fibroblastsR01NS107488 · NINDS · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2018 to 2022
$1.7M
NIA NIH HHS RF1 AG056296NINDS NIH HHS R01 NS107488
6 · The paper itself

Abstract

In this issue of Neuron, Amin et al. (2021) generate genetic tools to titrate down levels of miR-218, a motor neuron-enriched microRNA, in vivo. Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3' UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge.

Indexed as

MicroRNAsMotor Disorders3' Untranslated RegionsHumansMotor Neurons3' Untranslated RegionsMicroRNAsMIRN218 microRNA, human

Identifiers

PMID34672981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.