Evidence map›Paper›PMID 34672958›Full record

ArticleCell systems2021

Decomposing the mutational landscape of cancer genomes with RepairSig.

Sara Bernardo, Mathilde Meyenberg, Joanna I Loizou

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sara BernardoInstitute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria. Electronic address: sara.bernardo@meduniwien.ac.at.
Mathilde MeyenbergInstitute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Joanna I LoizouInstitute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. Electronic address: joanna.loizou@meduniwien.ac.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutational signatures are the outcomes of mutagenic processes that occur prior to, and during, tumorigenesis as a result of DNA damage, DNA repair, and DNA replication. In this issue of Cell Systems, Wojtowicz et al. introduce a new computational model aimed at deconstructing the mutational processes that shape cancer genomes.

Indexed as

NeoplasmsDNA DamageDNA RepairGenome, HumanHumansMutation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.