Evidence map›Paper›PMID 34672777›Full record

ArticleViral immunology2021

Decreased Activated CD4

Nicole E Skinner, Candelaria Vergara, Ramy El-Diwany, Harry Paul, Alyza Skaist, Sarah J Wheelan, David L Thomas, Stuart C Ray, Ashwin Balagopal, Justin R Bailey

Open access · greenAbstract read
In one paragraph

Article in Viral immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nicole E SkinnerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Candelaria VergaraDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ramy El-DiwanyDepartment of Surgery, and Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Harry PaulDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Alyza SkaistDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sarah J WheelanDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
David L ThomasDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Stuart C RayDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1051-7260
Ashwin BalagopalDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Justin R BaileyDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5704-3130
Johns Hopkins University · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
The Progression of Hepatitis C Among IDUs with HIVR01DA016078 · NIDA · JOHNS HOPKINS UNIVERSITY · PI BALAGOPAL, ASHWIN, THOMAS, DAVID L · 2002 to 2016
$10.9M
RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
The Impact of HCV Treatment in HIV/HCV coinfected and HCV monoinfected Incarcerated Persons on HCV EliminationR01DA013806 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IRVIN, RISHA, THOMAS, DAVID L · 2000 to 2024
$8.7M
Spatial Models of Intrahepatic Hepatitis C Virus Propagation in HumansR01AI116868 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI ASHWIN BALAGOPAL, Ruy M Ribeiro · 2016 to 2026
$8.5M
HIV HCV Coinfection Antiviral Therapy and FibrosisR37DA013806 · NIDA · JOHNS HOPKINS UNIVERSITY · PI THOMAS, DAVID L · 2010 to 2019
$7.0M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
NCATS NIH HHS UL1 TR000424NIAID NIH HHS R01 AI116868NIAID NIH HHS T32 AI007291NIDA NIH HHS R01 DA013806NIDA NIH HHS R01 DA016078NIDA NIH HHS R37 DA013806NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Dysfunctional immune activation accumulates during chronic viral infection and contributes to disease pathogenesis. In HIV-1, immune activation is exacerbated by concurrent infection with hepatitis C virus (HCV), accelerating depletion of CD4

Indexed as

CoinfectionHepatitis CHIV-1HIV InfectionsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-LymphocytesHumansantigenCD4-positive T lymphocytescoinfectionhepatitis CHIVimmune reconstitutionreceptorsT cell

Identifiers

PMID34672777
PMCPMC8917883
OpenAlexW3207477991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.