Evidence map›Paper›PMID 34672765›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Pathogenesis of obstructive sleep apnea in people living with HIV.

Jeremy E Orr, Bradley A Edwards, Christopher N Schmickl, Maile Karris, Pamela N DeYoung, Chantal Darquenne, Rebecca Theilmann, Sonia Jain, Atul Malhotra, Charles B Hicks and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  7. Diagnostic performance of screening tools for the detection of obstructive sleep apnea in people living with HIV.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  8. World AIDS Day 2021: highlighting the pulmonary complications of HIV/AIDS.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jeremy E OrrDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.ORCID 0000-0002-4498-5337
Bradley A EdwardsSleep and Circadian Medicine Laboratory, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.ORCID 0000-0001-9383-1644
Christopher N SchmicklDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.
Maile KarrisDivision of Infectious Disease, University of California San Diego, San Diego, California.
Pamela N DeYoungDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.
Chantal DarquenneDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.ORCID 0000-0001-5258-9089
Rebecca TheilmannDepartment of Radiology, University of California San Diego, San Diego, California.
Sonia JainHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, California.
Atul MalhotraDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.
Charles B HicksDivision of Infectious Disease, University of California San Diego, San Diego, California.
Robert L OwensDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.ORCID 0000-0002-6515-6204
University of California System · USUniversity of California San Diego · USAustralian Regenerative Medicine Institute · AU

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living with HIVR01HL142114 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR, OWENS, ROBERT LLEWELLYN · 2018 to 2021
$2.0M
The Impact of Sleep Disordered Breathing in People who use OpioidsK23HL151880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ORR, JEREMY ELLIOT · 2021 to 2025
$849k
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
NCATS NIH HHS UL1 TR001442NHLBI NIH HHS K23 HL151880NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL142114NHLBI NIH HHS R01HL142114NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS T32 HL134632NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is highly prevalent in people living with human immunodeficiency virus (HIV) (PLWH), and it might contribute to frequently reported symptoms and comorbidities. Traditional risk factors for OSA are often absent in PLWH, suggesting that HIV or HIV medications might predispose to OSA. Therefore, we measured the anatomical and nonanatomical traits important for OSA pathogenesis in those with and without HIV. We recruited virally suppressed PLWH who had been previously diagnosed with OSA (PLWH + OSA) adherent to positive airway pressure (PAP) therapy, along with age-, sex-, and body mass index (BMI)-matched OSA controls. All participants underwent a baseline polysomnogram to assess OSA severity and a second overnight research sleep study during which the airway pressure was adjusted slowly or rapidly to measure the OSA traits. Seventeen PLWH + OSA and 17 OSA control participants were studied [median age = 58 (IQR = 54-65) yr, BMI = 30.7 (28.4-31.8) kg/m

Indexed as

HIV InfectionsSleep Apnea, ObstructiveBody Mass IndexHumansMiddle AgedPolysomnographySleepfatigueHIVobstructive sleep apnea

Identifiers

PMID34672765
PMCPMC8714978
OpenAlexW3207496966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.