ArticleScience (New York, N.Y.)2021
General method for iron-catalyzed multicomponent radical cascades-cross-couplings.
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Iron Complexes Supported by a Rigid Macrocyclic PNPN Ligand.Inorganic chemistry · 2026Article
- Iron Catalyzed Aryl-Aryl Kumada Cross-Coupling: A Mechanistic and Computational Investigation.Angewandte Chemie (International ed. in English) · 2026Article
- Nickel-catalyzed ring-opening difunctionalization of methylenecyclobutanes via strain-release-enabled C-C activation.Nature communications · 2026Article
- Nickel-Catalyzed Twofold Conjunctive Coupling via Philicity-Alternating Radical Relay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Iron-mediated C(spTetrahedron · 2025Article
- Iron-catalysed radical difunctionalization of alkenes.Nature synthesis · 2025Article
- Influence of a Two-Fold Ligation Pattern on Iron-Mediated Aryl-Heteroaryl Cross-Electrophile Couplings.JACS Au · 2025Article
- Competition between One- and Two-Electron Unimolecular Reactions of Late 3d-Metal Complexes [(MeAngewandte Chemie (International ed. in English) · 2025Article
- Photocatalytic 1,3-difluoroalkylcarboxylation of alkenes by triple kinetic-controlled radical self-ordering.Chemical science · 2025Article
- Iron-Catalyzed Cross-Electrophile Coupling.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- C(spCommunications chemistry · 2025Article
- Iron-Catalyzed Aerobic Carbonylation of Methane via Ligand-to-Metal Charge Transfer Excitation.Journal of the American Chemical Society · 2025Article
- Effective Alkyl-Alkyl Cross-Coupling with an Iron-Xantphos Catalyst: Mechanistic and Structural Insights.Angewandte Chemie (International ed. in English) · 2025Article
- General Alkene 1,2-Journal of the American Chemical Society · 2024Article
- Chemoselective Cu-Catalyzed Cross-Nucleophile Alkylarylation of Alkenes.ACS catalysis · 2024Article
- Stereoselective Fe-Catalyzed Decoupled Cross-Couplings: Chiral Vinyl Oxazolidinones as Effective Radical Lynchpins for Diastereoselective C(spACS catalysis · 2024Article
- Fe-Catalyzed Fluoroalkyl(hetero)arylation of Vinyl Azaarenes: Rapid and Modular Synthesis of Unsymmetrical 1,1-Bis(hetero)arylalkanes.Organic letters · 2024Article
- Engaging Alkenes in Metallaphotoredox: A Triple Catalytic, Radical Sorting Approach to Olefin-Alcohol Cross-Coupling.Journal of the American Chemical Society · 2024Article
- Congested C(sp3)-rich architectures enabled by iron-catalysed conjunctive alkylation.Nature catalysis · 2024Article
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Abstract
Transition metal–catalyzed cross-coupling reactions are some of the most widely used methods in chemical synthesis. However, despite notable advantages of iron (Fe) as a potentially cheaper, more abundant, and less toxic transition metal catalyst, its practical application in multicomponent cross-couplings remains largely unsuccessful. We demonstrate 1,2-bis(dicyclohexylphosphino)ethane Fe–catalyzed coupling of α-boryl radicals (generated from selective radical addition to vinyl boronates) with Grignard reagents. Then, we extended the scope of these radical cascades by developing a general and broadly applicable Fe-catalyzed multicomponent annulation–cross-coupling protocol that engages a wide range of π-systems and permits the practical synthesis of cyclic fluorous compounds. Mechanistic studies are consistent with a bisarylated Fe(II) species being responsible for alkyl radical generation to initiate catalysis, while carbon-carbon bond formation proceeds between a monoarylated Fe(II) center and a transient alkyl radical.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.