ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2021
Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast.
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Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
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Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
- Frequency of germline pathogenic variants in breast cancer predisposing genes in a national cohort of young women with breast cancer.British journal of cancer · 2026Article
- Germline Multigene Panel Testing in Women With Invasive Lobular Cancer.JAMA network open · 2026Article
- Invasive ductal and lobular carcinoma and receptor status in the genetic context of breast cancer.Scientific reports · 2026Article
- Age-stratified analysis of invasive lobular carcinoma reveals comparable clinicopathological and molecular features across age groups.Discover oncology · 2026Article
- GermlinePathology oncology research : POR · 2026Article
- Breast Cancer Polygenic Risk Score Associated with Outcomes after In Situ Breast Disease.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- The Polynomial Progression Subtype Inference Algorithm.Research square · 2025Article
- Characterization of the Germline Pathogenic Mutational Landscape and Oncologic Outcomes Among 877 Patients with Invasive Lobular Carcinoma.Annals of surgical oncology · 2025Article
- Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity.NPJ breast cancer · 2025Review
- Hereditary diffuse gastric and lobular breast cancer syndrome associated with germline CDH1 variants: focus on lobular breast cancer.Journal of cancer research and clinical oncology · 2025Review
- Real-World Evidence on Prescribing Patterns and Clinical Outcomes of Metastatic Breast Cancer Patients Treated with PARP Inhibitors: The Mayo Clinic Experience.Clinical breast cancer · 2025Article
- Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes.NPJ breast cancer · 2025Review
- Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma In Situ of the Breast.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Occult Breast Cancer in High-Risk Gene-Positive Pakistani Women Undergoing Contralateral Prophylactic Mastectomy/Prophylactic Mastectomy: Implications for Sentinel Lymph Node Biopsy.Breast cancer : basic and clinical research · 2025Article
- Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025Review
- Breast Cancer Susceptibility Gene Sequence Variations and Development of Contralateral Breast Cancer.JAMA network open · 2024Article
- Review
- Triple-Negative Pleomorphic Lobular Carcinoma in a BRCA1 Mutation Carrier: A Case of Complete Pathological Response.The American journal of case reports · 2024Article
- Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation.Cold Spring Harbor perspectives in medicine · 2024Review
- Imaging for local recurrence of breast cancer.Journal of cancer research and clinical oncology · 2024Article
Corrections and comments
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Authors and funding
42 authors at 16 institutions in 1 country.
Siddhartha YadavMayo Clinic, Rochester, MN.ORCID 0000-0003-4630-9903
Chunling HuMayo Clinic, Rochester, MN.ORCID 0000-0002-6814-4639
Katherine L NathansonDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-6740-0901
Jeffrey N WeitzelLatin American School of Oncology, Sierra Madre, CA.ORCID 0000-0001-6714-092X
David E GoldgarUniversity of Utah, Salt Lake City, UT.ORCID 0000-0003-0697-9347
Peter KraftHarvard University T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0002-4472-8103
Rohan D GnanaolivuMayo Clinic, Rochester, MN.
Jie NaMayo Clinic, Rochester, MN.ORCID 0000-0003-3435-1805
Hongyan HuangHarvard University T.H. Chan School of Public Health, Boston, MA.
Nicholas J BoddickerMayo Clinic, Rochester, MN.ORCID 0000-0002-6784-2072
Nicole LarsonMayo Clinic, Rochester, MN.
Chi GaoHarvard University T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0002-8029-4496
Song YaoRoswell Park Comprehensive Cancer Center, Buffalo, NY.ORCID 0000-0001-9442-1313
Clarice WeinbergNIEHS, Durham, NC.
Celine M VachonMayo Clinic, Rochester, MN.ORCID 0000-0002-1962-9322
Amy Trentham-DietzUniversity of Wisconsin-Madison, Madison, WI.ORCID 0000-0002-5971-4660
Jack A TaylorNIEHS, Durham, NC.ORCID 0000-0001-5303-6398
Dale R SandlerNIEHS, Durham, NC.ORCID 0000-0002-6776-0018
Alpa PatelBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA.
Julie R PalmerSlone Epidemiology Center, Boston University, Boston, MA.ORCID 0000-0002-6534-335X
Janet E OlsonMayo Clinic, Rochester, MN.
Susan NeuhausenBeckman Research Institute of City of Hope, Duarte, CA.ORCID 0000-0001-5053-0390
Elena MartinezUniversity of California, San Diego, CA.ORCID 0000-0002-6728-1834
Sara LindstromFred Hutchinson Cancer Research Center, Seattle, WA.
James V LaceyBeckman Research Institute of City of Hope, Duarte, CA.
Allison W KurianStanford University School of Medicine, Stanford, CA.ORCID 0000-0002-6175-9470
Esther M JohnStanford University School of Medicine, Stanford, CA.ORCID 0000-0003-3259-8003
Christopher HaimanKeck School of Medicine, University of Southern California, Los Angeles, CA.
Leslie BernsteinBeckman Research Institute of City of Hope, Duarte, CA.ORCID 0000-0002-7692-6518
Paul W AuerUWM Joseph J. Zilber School of Public Health, Milwaukee, WI.
Hoda Anton-CulverUniversity of California, Irvine, CA.
Christine B AmbrosoneRoswell Park Comprehensive Cancer Center, Buffalo, NY.ORCID 0000-0003-1717-9943
Rachid KaramAmbry Genetics Inc, Aliso Viejo, CA.ORCID 0000-0002-5645-498X
Elizabeth ChaoAmbry Genetics Inc, Aliso Viejo, CA.
Amal YussufAmbry Genetics Inc, Aliso Viejo, CA.ORCID 0000-0002-7876-2713
Tina PesaranAmbry Genetics Inc, Aliso Viejo, CA.ORCID 0000-0001-9807-4304
Jill S DolinskyAmbry Genetics Inc, Aliso Viejo, CA.ORCID 0000-0002-3854-9539
Steven N HartMayo Clinic, Rochester, MN.ORCID 0000-0001-7714-2734
Holly LaDucaAmbry Genetics Inc, Aliso Viejo, CA.ORCID 0000-0002-3745-9072
Eric C PolleyMayo Clinic, Rochester, MN.ORCID 0000-0002-5152-8740
Susan M DomchekDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-5914-7272
Fergus J CouchMayo Clinic, Rochester, MN.ORCID 0000-0001-9417-9985
Mayo Clinic in Arizona · USAmbry Genetics (United States) · USCity of Hope · USHarvard University · USNational Institute of Environmental Health Sciences · USRoswell Park Comprehensive Cancer Center · USStanford University · USUniversity of Pennsylvania · USAmerican Cancer Society · USBoston University · USFred Hutch Cancer Center · USUniversity of California, Irvine · USUniversity of California San Diego · USUniversity of Southern California · USUniversity of Utah · USUniversity of Wisconsin–Madison · US
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3MUW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6MVIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MTwo-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6MTransgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MThe Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MCALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7MA Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0MLife Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MIntramural NIH HHS Z01 ES044005Intramural NIH HHS Z01 ES049033NCI NIH HHS K07 CA092044NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA151135NCI NIH HHS P30 CA014520NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA033572NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA047147NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA067264NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA097396NCI NIH HHS R01 CA098663NCI NIH HHS R01 CA100598NCI NIH HHS R01 CA185623NCI NIH HHS R01 CA192393NCI NIH HHS R01 CA204819NCI NIH HHS R01 CA225662NCI NIH HHS R35 CA253187NCI NIH HHS U01 CA082004NCI NIH HHS U01 CA164920NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA164974NCI NIH HHS U01 CA176726NCI NIH HHS U01 CA199277NCI NIH HHS UM1 CA164917NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018C
Abstract
purposeTo determine the contribution of germline pathogenic variants (PVs) in hereditary cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast. MATERIALS AND
methodsThe study included 2,999 women with ILC from a population-based cohort and 3,796 women with ILC undergoing clinical multigene panel testing (clinical cohort). Frequencies of germline PVs in breast cancer predisposition genes (
resultsThe frequency of PVs in breast cancer predisposition genes among women with ILC was 6.5% in the clinical cohort and 5.2% in the population-based cohort. In case-control analysis,
conclusionThe study establishes that PVs in
Indexed as
Genetic Predisposition to DiseaseGerm-Line MutationAdolescentAdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularCase-Control StudiesFemaleFollow-Up StudiesGenetic TestingHumansMiddle AgedBiomarkers, Tumor
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