Evidence map›Paper›PMID 34672377›Full record

ArticleJournal of medical virology2022

Long COVID syndrome-associated brain fog.

Ali A Asadi-Pooya, Ali Akbari, Amir Emami, Mehrzad Lotfi, Mahtab Rostamihosseinkhani, Hamid Nemati, Zohreh Barzegar, Maryam Kabiri, Zahra Zeraatpisheh, Mohsen Farjoud-Kouhanjani and 6 more

Abstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Pooled it
  6. Pooled it
  7. SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  8. Pooled it
  9. Returning to Work after the COVID-19 Pandemic Earthquake: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  10. Article
  11. Article
  12. Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026
    Review
  13. Article
  14. Article
  15. Review
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  18. Article
  19. Toward characterizing brain fog in long COVID: correlates and impact on measurement metrics.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ali A Asadi-PooyaEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-2598-7601
Ali AkbariDepartment of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Amir EmamiBurn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mehrzad LotfiMedical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahtab RostamihosseinkhaniEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Hamid NematiEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Zohreh BarzegarEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam KabiriEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra ZeraatpishehEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohsen Farjoud-KouhanjaniEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Anahita JafariEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sarvin SasanniaEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shayan AshrafiEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Masoume NazeriEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sara NasiriEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mina ShahisavandiEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the frequency of brain fog in a large cohort of patients with documented coronavirus disease-2019 (COVID-19) who have survived the illness. We also scrutinized the potential risk factors associated with the development of brain fog. Adult patients (18-55 years of age), who were referred to the healthcare facilities anywhere in Fars province from February 19, 2020 to November 20, 2020 were included. All patients had a confirmed COVID-19 diagnosis. In a phone call, at least 3 months after their discharge from the hospital, we obtained their current information. A questionnaire was specifically designed for data collection. In total, 2696 patients had the inclusion criteria; 1680 (62.3%) people reported long COVID syndrome (LCS). LCS-associated brain fog was reported by 194 (7.2%) patients. Female sex (odds ratio [OR]: 1.4), respiratory problems at the onset (OR: 1.9), and intensive care unit (ICU) admission (OR: 1.7) were significantly associated with reporting chronic post-COVID "brain fog" by the patients. In this large population-based study, we report that chronic post-COVID "brain fog" has significant associations with sex (female), respiratory symptoms at the onset, and the severity of the illness (ICU admission).

Indexed as

COVID-19AdultBrainCOVID-19 TestingFemaleHumansPost-Acute COVID-19 SyndromeSARS-CoV-2braincoronavirusCOVID-19SARS-CoV-2

Identifiers

PMID34672377
PMCPMC8662118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.